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Global Health: Science and Practice

Dedicated to what works in global health programs

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Tuberculosis

  • Open Access
    Leveraging Experience From Active TB Drug-Safety Monitoring and Management for Monitoring Active Antiretroviral Toxicity
    Lisa Stevens, Kelly E. Perry, Iakuna Moide, Francil Kaemala, Justine Nankinga, Anh L. Innes and Ignatius Mogaba
    Global Health: Science and Practice April 2022, 10(2):e2100595; https://doi.org/10.9745/GHSP-D-21-00595

    Systems established for active drug safety monitoring and management of drug-resistant TB should be leveraged to ensure comprehensive surveillance for active toxicity monitoring during scale-up of newer antiretroviral regimens.

  • Open Access
    Using a Pharmacy-Based Surveillance System to Improve Standards for TB Care in Kerala, India
    Rakesh PS, Shibu Balakrishnan, Rakesh Ramachandran, Smitha Nandhan, Nidhish Issac Samuel, Pramodkumar PP and Suja Aloysius
    Global Health: Science and Practice December 2021, 9(4):846-854; https://doi.org/10.9745/GHSP-D-21-00346

    A pharmacy-based surveillance system in Kerala, India, has helped to improve TB patient notifications from the private sector, build better public-private partnerships, and improve the quality of TB diagnosis. Pharmacy-based surveillance has the potential to strengthen TB surveillance and facilitate standards of TB care.

  • Open Access
    Lessons Learned During the COVID-19 Pandemic to Strengthen TB Infection Control: A Rapid Review
    Helena J. Chapman and Bienvenido A. Veras-Estévez
    Global Health: Science and Practice December 2021, 9(4):964-977; https://doi.org/10.9745/GHSP-D-21-00368

    In light of competing health priorities of COVID-19 and TB, we propose recommendations to strengthen health system preparedness for optimal TB control across low- and middle-income countries during and after the COVID-19 pandemic.

  • Open Access
    A Quality Improvement Intervention to Inform Scale-Up of Integrated HIV-TB Services: Lessons Learned From KwaZulu-Natal, South Africa
    Santhanalakshmi Gengiah, Kogieleum Naidoo, Regina Mlobeli, Maureen F. Tshabalala, Andrew J. Nunn, Nesri Padayatchi, Nonhlanhla Yende-Zuma, Myra Taylor, Pierre M. Barker and Marian Loveday
    Global Health: Science and Practice September 2021, 9(3):444-458; https://doi.org/10.9745/GHSP-D-21-00157

    Despite being standard of care, gaps in HIV-TB service delivery are present. Quality Improvement methods are effective in uncovering health systems weaknesses that impede efficient delivery of integrated HIV-TB services.

  • Open Access
    Implementation of GeneXpert for TB Testing in Low- and Middle-Income Countries: A Systematic Review
    Scott Brown, Justine E. Leavy and Jonine Jancey
    Global Health: Science and Practice September 2021, 9(3):698-710; https://doi.org/10.9745/GHSP-D-21-00121

    This review highlights a commonality of implementation barriers across geographically dispersed GeneXpert interventions for TB testing. This indicates the importance of using implementation frameworks to report findings that can improve public health outcomes across low- and middle-income countries.

  • Open Access
    STEPS: A Solution for Ensuring Standards of TB Care for Patients Reaching Private Hospitals in India
    Shibu Balakrishnan, Rakesh PS, Sunilkumar M, Bhavan Sankar, Rakesh Ramachandran, Ameer KA, Ramani Gopi and Prem Nair
    Global Health: Science and Practice June 2021, 9(2):286-295; https://doi.org/10.9745/GHSP-D-20-00449

    A low-cost model for engaging the private sector to address gaps in TB care and ensuring that patients in the private sector receive the standards of care in India was feasible. The pilot project showed improvements in standards of care, which benefits the patient, government, private hospitals, and society.

  • Open Access
    Diagnostic Utility and Impact on Clinical Decision Making of Focused Assessment With Sonography for HIV-Associated Tuberculosis in Malawi: A Prospective Cohort Study
    Daniel Kahn, Kara-Lee Pool, Linna Phiri, Florence Chibwana, Kristin Schwab, Levison Longwe, Ben Allan Banda, Khumbo Gama, Mayamiko Chimombo, Chifundo Chipungu, Jonathan Grotts, Alan Schooley and Risa M. Hoffman
    Global Health: Science and Practice March 2020, 8(1):28-37; https://doi.org/10.9745/GHSP-D-19-00251

    Among patients with HIV and with probable/confirmed TB, using the focused assessment with sonography for HIV-associated TB (FASH) protocol led to a 5-fold increase in the clinician's decision to initiate TB treatment on that day. FASH is a supplementary tool that can help clinicians diagnose patients with HIV-associated TB at the point-of-care and reduce delays in their treatment, particularly when access to other diagnostics is limited or unavailable.

  • Open Access
    Realizing the “40 by 2022” Commitment From the United Nations High-Level Meeting on the Fight to End Tuberculosis: What Will It Take to Meet Rapid Diagnostic Testing Needs?
    Amy S. Piatek, William A. Wells, Kaiser C. Shen and Charlotte E. Colvin
    Global Health: Science and Practice December 2019, 7(4):551-563; https://doi.org/10.9745/GHSP-D-19-00244

    Existing rapid diagnostics offer faster and more sensitive diagnosis of tuberculosis (TB) and simultaneous detection of multidrug-resistant TB. A 5-fold increase in investment in these tools is needed to meet the needs of the TB community and the United Nations’ ambitious 40 million by 2022 diagnosis and treatment target.

  • Open Access
    Scale and Ambition in the Engagement of Private Providers for Tuberculosis Care and Prevention
    William A. Wells
    Global Health: Science and Practice March 2019, 7(1):3-5; https://doi.org/10.9745/GHSP-D-19-00074

    The tuberculosis (TB) community knows the importance of engaging private providers to reach critical TB targets, and knows how to engage successfully. The next challenge is to transition such efforts to government stewardship and financing in order to reach scale.

  • Open Access
    Successfully Engaging Private Providers to Improve Diagnosis, Notification, and Treatment of TB and Drug-Resistant TB: The EQUIP Public-Private Model in Chennai, India
    Ramya Ananthakrishnan, M. D'Arcy Richardson, Susan van den Hof, Radha Rangaswamy, Rajeswaran Thiagesan, Sheela Auguesteen and Netty Kamp
    Global Health: Science and Practice March 2019, 7(1):41-53; https://doi.org/10.9745/GHSP-D-18-00318

    Based on a participatory program design that addressed the self-described needs of private providers, a local NGO offered the providers access to rapid diagnostics and support for notification and patient treatment including free anti-TB drugs. The model resulted in high provider participation, contributing more than 10% of the overall TB case notifications, and an 89% treatment success rate for drug-sensitive TB.

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US AIDJohns Hopkins Center for Communication ProgramsUniversity of Alberta

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