Intrauterine growth retardation (IUGR) has been linked to the onset of diseases in adulthood,
including type 2 diabetes, and has been proposed to result from altered gene regulation …

Uteroplacental insufficiency resulting in fetal growth retardation is a common complication
of pregnancy and a significant cause of perinatal morbidity and mortality. Epidemiological …

Intrauterine growth retardation has been linked to the development of type 2 diabetes in later
life. The mechanisms underlying this phenomenon are unknown. We have developed a …

There is currently little information available about how individual cell types contribute to
Alzheimer’s disease. Here we applied single-nucleus RNA sequencing to entorhinal cortex …

Periventricular white matter injury (PWMI) is the leading cause of chronic neurologic injury
among survivors of preterm birth. The hallmark of PWMI is hypomyelination and a lack of …

Background Single-cell RNA sequencing has been widely adopted to estimate the cellular
composition of heterogeneous tissues and obtain transcriptional profiles of individual cells. …

The role of microglia cells in Alzheimer’s disease (AD) is well recognized, however their
molecular and functional diversity remain unclear. Here, we isolated amyloid plaque-containing (…

OBJECTIVE To estimate the benefits of screening and early treatment of type 2 diabetes
compared with no screening and late treatment using a simulation model with data from the …

Background The increasing prevalence of type 2 diabetes poses a major public health
challenge. Population-based screening and early treatment for type 2 diabetes could reduce this …

It has long been understood that the pathogenesis of complex diseases such as diabetes
includes both genetic and environmental components. More recently, it has become clear that …