Protein therapy exhibits several advantages over small molecule drugs and is increasingly
being developed for the treatment of disorders ranging from single enzyme deficiencies to …

Air pollution is a significant cause of cardiovascular morbidity and mortality worldwide.
Although the epidemiologic association between air pollution exposures and exacerbation of …

Rationale: Mitochondrial dysfunction has been implicated in several cardiovascular diseases;
however, the roles of mitochondrial oxidative stress and DNA damage in hypertensive …

Objectives. The purpose of this study was to better understand the effects of long-term right
ventricular pacing on left ventricular perfusion, innervation, function and histology. …

Human atherosclerotic lesions overexpress the lysosomal cysteine protease cathepsin S (Cat
S), one of the most potent mammalian elastases known. In contrast, atheromata have low …

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder,
affecting 1 in 500 people in the general population. Although characterized by asymmetric …

An algorithmic analog-to-digital conversion technique is described which is capable of achieving
high-resolution conversion without the use of matched capacitors in an MOS technology…

Hepatitis C virus (HCV) is a major cause of chronic hepatitis. The virus does not replicate
efficiently in cell cultures, and it is therefore difficult to assess infection-neutralizing antibodies …

Background— Notch signaling influences binary cell fate decisions in a variety of tissues. The
Notch1 receptor is widely expressed during embryogenesis and is essential for embryonic …

Objective. —To describe and compare with standard cardiopulmonary resuscitation (CPR)
in humans a new form of CPR that involves both active compression and active …