The Jamkhed Comprehensive Rural Health Project (Jamkhed CRHP) was established in central India in 1970. The Jamkhed CRHP approach, developed by Rajanikant and Mabelle Arole, was instrumental in influencing the concepts and principles embedded in the 1978 Declaration of Alma-Ata. The Jamkhed CRHP pioneered provision of services close to people's homes, use of health teams (including community workers), community engagement, integration of services, and promotion of equity, all key elements of the declaration. The extraordinary contributions that the Jamkhed CRHP has made as it approaches its 50th anniversary need to be recognized as the world celebrates the 40th anniversary of the International Conference on Primary Health Care and the writing of the declaration. We describe the early influence of the Jamkhed CRHP on the declaration as well as the work at Jamkhed, its notable influence in improving the health of the people it has served and continues to serve, the remarkable contributions it has made to training people from around India and the world, and its remarkable influences on programs and policies in India and beyond.