Health Care Workers as key players in the prevention and management of diseases and important opinion and community leaders have become targets for studies, more so with the outbreak of HIV. Their perceptions, attitudes and practices have implications for the management of diseases in both health centres and communities. This study reports some of the results of in-depth interviews with Health Care Workers in the Cape Coast municipality (Ghana) on their perception of risk of exposure to HIV, attitudes to known persons with HIV/AIDS, counselling and confidentiality. Results indicate a general fear of infection given the working environment and conditions such as the insufficient supply of basic items, and inadequate information on the sero-status of some patients. Although aware of the basic precautions needed to avoid infection, some health workers did not follow them. There was also a lack of consensus among them on the issues of confidentiality and responsibility towards a discordant partner. The main arguments were those of the general debate between safeguarding individual rights and protecting the common good. It is important for the medical establishment to debate the issue so that the rights of some individuals are not compromised.