<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hodgins, Stephen</style></author><author><style face="normal" font="default" size="100%">Mathai, Matthews</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Low-Dose Antenatal Calcium Supplementation: An Intervention Ready for Prime Time</style></title><secondary-title><style face="normal" font="default" size="100%">Global Health: Science and Practice</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2024-02-28 00:00:00</style></date></pub-dates></dates><elocation-id><style  face="normal" font="default" size="100%">e2400074</style></elocation-id><doi><style  face="normal" font="default" size="100%">10.9745/GHSP-D-24-00074</style></doi><volume><style face="normal" font="default" size="100%">12</style></volume><issue><style face="normal" font="default" size="100%">1</style></issue><abstract><style  face="normal" font="default" size="100%">On January 11, 2024, the New England Journal of Medicine published an article reporting the results of a non-inferiority study comparing low- vs. high-dose antenatal supplementation in populations with low calcium intake, with the primary endpoints being preeclampsia and preterm birth.1 This study has important implications for maternal and newborn health programs in low- and lower-middle-income countries where calcium intake is low.Preeclampsia/eclampsia (PE/E) is second only to hemorrhage as a direct cause of maternal deaths and is estimated to account for about 14% of maternal deaths.2 According to data from a 6-country World Health Organization (WHO) study,3 PE/E is the primary obstetrical cause for 24% of perinatal deaths. For decades, there has been evidence of an association between low calcium intake and risk of PE/E.4Trials in the first decade of this century, notably a large 6-country study by WHO,5 provided evidence for the efficacy of antenatal calcium supplementation for preventing severe PE/E. The WHO study used a dose of 1.5 g/day of elemental calcium in …</style></abstract></record></records></xml>