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METHODOLOGY
Open Access

Systematic Process Framework for Conducting Implementation Science Research in Food Fortification Programs

Emily Teachout, Laura A. Rowe, Helena Pachon, Becky L. Tsang, Lorraine F. Yeung, Jorge Rosenthal, Hilda Razzaghi, Meredith Moore, Dora Panagides, Peiman Milani and Michael J. Cannon
Global Health: Science and Practice June 2021, 9(2):412-421; https://doi.org/10.9745/GHSP-D-20-00707
Emily Teachout
aCenters for Disease Control and Prevention, Atlanta, GA, USA.
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  • For correspondence: NKH6{at}cdc.gov
Laura A. Rowe
bFood Fortification Initiative, Atlanta, GA, USA.
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Helena Pachon
bFood Fortification Initiative, Atlanta, GA, USA.
cEmory University, Atlanta, GA, USA.
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Becky L. Tsang
bFood Fortification Initiative, Atlanta, GA, USA.
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Lorraine F. Yeung
aCenters for Disease Control and Prevention, Atlanta, GA, USA.
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Jorge Rosenthal
aCenters for Disease Control and Prevention, Atlanta, GA, USA.
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Hilda Razzaghi
aCenters for Disease Control and Prevention, Atlanta, GA, USA.
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Meredith Moore
aCenters for Disease Control and Prevention, Atlanta, GA, USA.
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Dora Panagides
dWorld Food Programme, Rome, Italy.
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Peiman Milani
eWorld Food Programme, Nairobi, Kenya.
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Michael J. Cannon
aCenters for Disease Control and Prevention, Atlanta, GA, USA.
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    FIGURE 1

    Systematic Process Framework for Conducting Implementation Science Research in Food Fortification Programs

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    FIGURE 2

    Example of a Theory of Change Model for Food Fortificationa

    a Created by members of the Global Fortification Technical Advisory Group.

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    FIGURE 3

    Example of Phase I, Step 2 of Food Fortification Implementation Framework

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    FIGURE 4

    Possible Next Steps After the Conclusion of an Implementation Research Study

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    TABLE 1.

    Implementation Outcome Variables Contextualized for Food Fortification19

    Implementation Outcome VariableWorking Definition in the Context of Food FortificationRelated Terms in Food Fortification (Non-exhaustive)Examples of Interpretations for Food Fortification Programs (Non-exhaustive)
    AcceptabilityThe degree to which food fortification (or an innovation that addresses a precondition to the increased consumption of adequately fortified foods) is agreeable to stakeholdersPerceived operability; myths, taboos, and beliefs; perceived cost- benefit; perceived affordability; perceived business advantage or disadvantage; organoleptic/sensory propertiesAcceptability of food fortification technology by industry; acceptability of the intervention by policy makers; acceptability of the addition of micronutrients to food by consumers; acceptability of a price increase by consumers
    AdoptionThe uptake, utilization, intention to try or intention to consume any product, activity, or innovation related to food fortificationUptake; penetration; utilization; intention to try or intention to buy/consumeAdoption of food fortification by producers; adoption of a fortification logo; use or intended use of fortified products by consumers
    Appropriateness/ FeasibilityThe perceived (or actual) fit, relevance, or compatibility of food fortification for a particular context; the ability of food fortification to reach a particular target group (e.g., women of reproductive age who are below the poverty line)Practicality; perceived fit; relevance; suitability; operabilityAppropriateness of the food selected to fortify; appropriateness of the micronutrient compound being used by food processors; feasibility of fortification in the context of the state of the production industry (e.g., centralized vs decentralized processing); appropriateness of the technology being used by producers; appropriateness of the intervention to address a particular micronutrient deficiency; feasibility to enforce legislation
    CoverageThe degree to which the targeted population is consuming fortified products regularly or able to access fortified productsReach; access; penetration; consumption amongst the population; coverage of the target populationPenetration of fortified products in the market; percentage of the population that can access fortified products
    FidelityThe degree to which activities related to food fortification are occurring according to original program plan, policy, or protocolsCompliance; adherence; quality; delivery as intendedCompliance of the micronutrient compound with national standards; compliance of micronutrient levels found in foods with allowable ranges that are specified by national standards
    Implementation CostThe total cost of implementing all activities related to achieving increased consumption of adequately fortified foodsProgram costTotal cost per beneficiary of reaching 80% coverage of fortified foods
    SustainabilityThe extent to which fortification is institutionalized within the government and industry and not reliant on continuous external inputs and supportInstitutionalization; integration; non-reliance on external inputs; ownership by the government, industry, and societyDegree to which the government can monitor and enforce food fortification; degree to which complying with fortification requirements is a viable business model for producers
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    TABLE 2.

    Template for Prioritizing Implementation Research Questions21

    Example
    Program outcome and underlying assumption/determinantIncreased access to fortified products. Fortified products are affordable and available for urban populations
    Research question(s)What is the national coverage of fortified products amongst the urban poor?
    How will the success of the intervention be affected by the information provided?The urban poor are a large proportion of our target population. If we are not currently reaching them, we will need to adjust our program with new targeting strategies.
    Possible research methodsSecondary analysis of existing data set
    Organization/persons responsible for conducting the researchThe National Micronutrient Committee
    Resources, support, or training required by the organization/personsHuman resources to analyze data and write report
    Estimated costNo additional cost to program
    Estimated time to prepare for and conduct the research6–8 weeks
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    TABLE 3.

    Implementation Research Objectives With Examples for Food Fortification Programsa

    Research ObjectiveDescriptionExamples
    To describeDescribes the context in which food fortification is occurring and the main components that may affect the success of food fortificationWhat proportion of the population consumes wheat flour that is produced in industrial mills?
    To exploreExplores the possible barriers and facilitators to the implementation of food fortificationWhat are the barriers and facilitators for implementing adequate external quality assurance/quality control?
    To explainExplains how and why certain aspects of the intervention or the context may influence implementation outcomesHow do market prices affect revenue margins for wheat flour millers?
    To influenceTests desired effects of an implementation improvement strategyDoes additional training and fortification sensitization of millers lead to better fortification of a product?
    To predictPredicts whether the same (or modified version of) aspects of a food fortification program will work under various conditions (useful for scale-up)Will the radio advocacy materials that increased fortification logo awareness in the southern parts of the country also produce similar results in the northern parts of the country?
    • ↵a Adapted from Peters DH, Tran NT, Taghreed A. Implementation Research in Health: A Practical Guide. World Health Organization; 2013.

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Global Health: Science and Practice: 9 (2)
Global Health: Science and Practice
Vol. 9, No. 2
June 30, 2021
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Systematic Process Framework for Conducting Implementation Science Research in Food Fortification Programs
Emily Teachout, Laura A. Rowe, Helena Pachon, Becky L. Tsang, Lorraine F. Yeung, Jorge Rosenthal, Hilda Razzaghi, Meredith Moore, Dora Panagides, Peiman Milani, Michael J. Cannon
Global Health: Science and Practice Jun 2021, 9 (2) 412-421; DOI: 10.9745/GHSP-D-20-00707

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Systematic Process Framework for Conducting Implementation Science Research in Food Fortification Programs
Emily Teachout, Laura A. Rowe, Helena Pachon, Becky L. Tsang, Lorraine F. Yeung, Jorge Rosenthal, Hilda Razzaghi, Meredith Moore, Dora Panagides, Peiman Milani, Michael J. Cannon
Global Health: Science and Practice Jun 2021, 9 (2) 412-421; DOI: 10.9745/GHSP-D-20-00707
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