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ORIGINAL ARTICLE
Open Access

Factors Associated With Delayed Contraceptive Implant Removal in Ethiopia

Elizabeth Costenbader, Alice F. Cartwright, Misti McDowell, Berhane Assefa, Meza Yirga Tejeji and Eskindir Tenaw
Global Health: Science and Practice September 2020, 8(3):000; https://doi.org/10.9745/GHSP-D-20-00135
Elizabeth Costenbader
aFHI 360, Durham, NC, USA.
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  • For correspondence: bcostenbader@fhi360.org
Alice F. Cartwright
bDepartment of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Misti McDowell
cFHI 360-Ethiopia, Addis Ababa, Ethiopia.
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Berhane Assefa
dFederal Ministry of Health, Addis Ababa, Ethiopia.
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Meza Yirga Tejeji
cFHI 360-Ethiopia, Addis Ababa, Ethiopia.
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Eskindir Tenaw
cFHI 360-Ethiopia, Addis Ababa, Ethiopia.
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  • RE: delay in removal up to 5 years carries very little risk of contraceptive failure
    Noel McIntosh
    Published on: 28 August 2020
  • Published on: (28 August 2020)
    Page navigation anchor for RE: delay in removal up to 5 years carries very little risk of contraceptive failure
    RE: delay in removal up to 5 years carries very little risk of contraceptive failure
    • Noel McIntosh, Retired, NA

    Given that a study in 2018 reported no (zero) pregnancies in women leaving their etonogestrel implants in for five years, I am not sure how important the findings in this study are. At least the authors should have mentioned that delay in removal up to five years carries very little risk of contraceptive failure.

    Jacobs M. Treatment Duration for Etonogestrel Implants. Am Fam Physician. 2018 Aug 1;98(3):online. https://www.aafp.org/afp/2018/0801/od3.html

    Treatment Duration for Etonogestrel Implant

    Clinical Question

    Is the etonogestrel subdermal implant (Nexplanon) effective beyond the recommended three-year treatment duration?

    Evidence-Based Answer

    The etonogestrel subdermal implant is approved by the U.S. Food and Drug Administration for contraception for up to three years, but it seems to be effective for up to five years. (Strength of Recommendation [SOR]: B, based on a randomized controlled trial and prospective cohort study.) When the implant is used for up to five years, failure rates are the same among women who are normal weight, overweight, or obese. (SOR: B, based on a prospective cohort study.)

    Evidence Summary

    A 2016 open-label, multicenter trial compared 390 patients who agreed to extend their three-year etonogestrel single-rod implant an additional two years with 522 participants who had the five-year dual-rod levonorgestrel implant (Norplant).1 Fi...

    Show More

    Given that a study in 2018 reported no (zero) pregnancies in women leaving their etonogestrel implants in for five years, I am not sure how important the findings in this study are. At least the authors should have mentioned that delay in removal up to five years carries very little risk of contraceptive failure.

    Jacobs M. Treatment Duration for Etonogestrel Implants. Am Fam Physician. 2018 Aug 1;98(3):online. https://www.aafp.org/afp/2018/0801/od3.html

    Treatment Duration for Etonogestrel Implant

    Clinical Question

    Is the etonogestrel subdermal implant (Nexplanon) effective beyond the recommended three-year treatment duration?

    Evidence-Based Answer

    The etonogestrel subdermal implant is approved by the U.S. Food and Drug Administration for contraception for up to three years, but it seems to be effective for up to five years. (Strength of Recommendation [SOR]: B, based on a randomized controlled trial and prospective cohort study.) When the implant is used for up to five years, failure rates are the same among women who are normal weight, overweight, or obese. (SOR: B, based on a prospective cohort study.)

    Evidence Summary

    A 2016 open-label, multicenter trial compared 390 patients who agreed to extend their three-year etonogestrel single-rod implant an additional two years with 522 participants who had the five-year dual-rod levonorgestrel implant (Norplant).1 Five-year pregnancy rates were similar between the groups: 0.6 per 100 woman-years (95% confidence interval [CI], 0.2 to 1.8) in the etonogestrel group vs. 0.8 per 100 woman-years (95% CI, 0.2 to 2.3) in the levonorgestrel group. No pregnancies occurred in either group during years 4 and 5. More women in the etonogestrel group reported heavy bleeding during years 4 and 5 (1.4 and 3.4 per 100 women in years 4 and 5, respectively, vs. 0.8 and 2.3 per 100 women in the levonorgestrel group; P < .05).

    An ongoing prospective cohort study that started in 2009 and reported data in 2017 enrolled patients with an etonogestrel implant who were willing to continue its use for an additional two years.2 Etonogestrel levels were obtained periodically and stratified by the women's body mass index. Unintended pregnancies were calculated per 100 woman-years. Thus far, 291 women in years 4 and 5 of use have completed 444 woman-years of follow-up with no pregnancies. The failure rate has been calculated at 0 (one-sided 97.5% CI, 0 to 1.5 for four-year use and 0 to 2.7 for five-year use per 100 woman-years). Median etonogestrel levels were statistically different between groups but remained above the threshold for ovulation.

    Address correspondence to Mollie Jacobs, MD, at mollie.jacobs@ucdenver.edu. Reprints are not available from the author.

    Author disclosure: No relevant financial affiliations.

    References

    1. Ali M, Akin A, Bahamondes L, et al.; WHO study group on subdermal contraceptive implants for women. Extended use up to 5 years of the etonogestrel-releasing subdermal contraceptive implant: comparison to levonorgestrel-releasing subdermal implant. Hum Reprod. 2016;31(11):2491–2498.

    2. McNicholas C, Swor E, Wan L, Peipert JF. Prolonged use of the etonogestrel implant and levonorgestrel intrauterine device: 2 years beyond the Food and Drug Administration-approved duration. Am J Obstet Gynecol. 2017;216(6):586.e1–586.e6.

    Show Less
    Competing Interests: None declared.
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Global Health: Science and Practice: 8 (3)
Global Health: Science and Practice
Vol. 8, No. 3
September 30, 2020
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Factors Associated With Delayed Contraceptive Implant Removal in Ethiopia
Elizabeth Costenbader, Alice F. Cartwright, Misti McDowell, Berhane Assefa, Meza Yirga Tejeji, Eskindir Tenaw
Global Health: Science and Practice Sep 2020, 8 (3) 000; DOI: 10.9745/GHSP-D-20-00135

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Factors Associated With Delayed Contraceptive Implant Removal in Ethiopia
Elizabeth Costenbader, Alice F. Cartwright, Misti McDowell, Berhane Assefa, Meza Yirga Tejeji, Eskindir Tenaw
Global Health: Science and Practice Sep 2020, 8 (3) 000; DOI: 10.9745/GHSP-D-20-00135
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