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VIEWPOINT
Open Access

Multimonth Dispensing of Antiretroviral Therapy Protects the Most Vulnerable From 2 Pandemics at Once

Ariana Moriah Traub, Temitayo Ifafore-Calfee and Benjamin Ryan Phelps
Global Health: Science and Practice June 2020, 8(2):176-177; https://doi.org/10.9745/GHSP-D-20-00160
Ariana Moriah Traub
aSustaining Technical and Analytic Resources, United States Agency for International Development (USAID), Washington, DC, USA.
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  • For correspondence: atraub@usaid.gov
Temitayo Ifafore-Calfee
bOffice of HIV/AIDS, USAID, Washington, DC, USA.
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Benjamin Ryan Phelps
bOffice of HIV/AIDS, USAID, Washington, DC, USA.
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Key Messages

  • Multimonth dispensing, which provides patients with several months of antiretroviral therapy, benefits HIV patients by decreasing the number of required clinic visits, improving retention, and improving viral suppression.

  • With the increased spread of severe acute respiratory syndrome coronavirus 2, we encourage governments, ministries of health, and health care facilities to implement multimonth dispensing for patients with HIV who are stable to reduce clinic visits and safeguard both health care workers and patients from coronavirus disease 2019.

Since the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, the virus has been identified in more than 183 countries.1 Its rapid spread is of major concern for those living in low- and middle-income countries and specifically people living with HIV (PLHIV). With the dearth of studies on HIV-coronavirus disease 2019 (COVID-19) coinfections, countries have no clear evidence on specific risks for PLHIV.2,3 However, as with other infectious diseases, it is expected that PLHIV who are not virally suppressed and/or on antiretroviral therapy (ART) might be at an increased risk of COVID-19 infection, severe disease, and poor health outcomes.2,3 Thus, every precaution must be taken to avoid HIV-COVID-19 coinfection and keep the number of COVID-19 cases at a minimum in countries with high proportions of PLHIV.

To minimize the spread of COVID-19, PLHIV are encouraged to follow public health guidelines to limit in-person interactions and general mitigation recommendations, including social distancing and good hand hygiene. Refilling lifesaving antiretroviral drugs requires interpersonal interaction and brings the potential of increasing the spread of SARS-CoV-2 and other transmissible diseases. Thus, policy makers—including the U.S. President’s Emergency Plan for AIDS Relief—are encouraging countries to provide PLHIV with a multimonth supply of ART as a key strategy to safeguard PLHIV and health care workers involved in providing HIV services.4

MULTIMONTH ART DISPENSING MITIGATES RISK OF HIV AND COVID-19

Multimonth dispensing (MMD) is an aspect of differentiated service delivery that provides patients with either 3 or 6 months of medication and eliminates the need for monthly clinic and/or community facility visits. From the patient’s perspective, MMD has already been shown to reduce the cost of travel, reduce patient burden, and limit the hours of work or school lost.5,6 Importantly, MMD improves adherence and viral suppression.5,7 In the context of the COVID-19 pandemic, this viral suppression strengthens the immune system and likely mitigates the risk of severe COVID-19.8 MMD, essential to caring for PLHIV, is arguably even more critical during the COVID-19 pandemic.

Currently, only 21 countries have formal 6-month dispensing policies. Two countries allow clinicians to provide 6-month supply when they deem appropriate, and 8 countries have a 3-month dispensing policy in place. South Africa, the country with the largest number of PLHIV, only has a 2-month dispensing policy in place.

To mitigate the damage caused by SARS-CoV-2 while protecting the health of PLHIV, we encourage countries to rapidly implement 3-month if not 6-month dispensing. As a key strategy to safeguard patients and health care workers providing HIV services, MMD also reduces clinic visits, improves viral suppression, encourages social distancing, and potentially saves patients from the dual threat of SARS-CoV-2 and HIV. As SARS-CoV-2 spreads, patient caseloads are likely to increase across low- and middle-income countries where HIV burden is high and millions of people are stable on effective treatment. Implementing MMD quickly will protect the time and health of existing health care professionals and ready our health systems for imminent threats as well as any that may follow.

Notes

Peer Reviewed

Disclaimer: The views expressed in this article are solely the views of the authors and do not necessarily reflect the views of the United States Agency for International Development or the United States Government.

Cite this article as: Traub AM, Ifafore-Calfee T, Phelps B. Multimonth dispensing of antiretroviral therapy protects the most vulnerable from 2 pandemics at once. Glob Health Sci Pract. 2020;8(2):176-177. https://doi.org/10.9745/GHSP-D-20-00160

  • Received: April 16, 2020.
  • Accepted: May 6, 2020.
  • Published: June 30, 2020.
  • © Traub et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly cited. To view a copy of the license, visit http://creativecommons.org/licenses/by/4.0/. When linking to this article, please use the following permanent link: https://doi.org/10.9745/GHSP-D-20-00160

REFERENCES

  1. 1.↵
    1. Dong E,
    2. Du H,
    3. Gardner L
    . An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis. 2020. doi:10.1016/s1473-3099(20)30120-1. pmid:32087114
    OpenUrlCrossRefPubMed
  2. 2.↵
    Centers for Disease Control and Prevention. What to Know About HIV and COVID-19. https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/hiv.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fspecific-groups%2Fhiv.html. Updated March 18, 2020. Accessed March 31, 2020.
  3. 3.↵
    U.S. Department of Health and Human Services. Interim Guidance for COVID-19 and Persons with HIV. https://aidsinfo.nih.gov/guidelines/html/8/covid-19-and-persons-with-hiv–interim-guidance-/554/interim-guidance-for-covid-19-and-persons-with-hiv. Updated April 21, 2020. Accessed March 31, 2020.
  4. 4.↵
    U.S. President’s Emergency Plan for AIDS Relief. PEPFAR’s HIV Response in the Context of Coronavirus Disease 2019 (COVID-19). https://www.state.gov/pepfar/coronavirus/. Published March 25, 2020. Accessed April 9, 2020.
  5. 5.↵
    1. Faturiyele IO,
    2. Appolinare T,
    3. Ngorima-Mabhena N, et al
    . Outcomes of community-based differentiated models of multi-month dispensing of antiretroviral medication among stable HIV-infected patients in Lesotho: a cluster randomised non-inferiority trial protocol. BMC Public Health. 2018;18(1):1069. doi:10.1186/s12889-018-5961-0. pmid:30157896
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Babigumira JB,
    2. Castelnuevo B,
    3. Stergachis A, et al
    . Cost effectiveness of a pharmacy-only refill program in a large urban HIV/AIDS clinic in Uganda. PloS One. 2011;6(3):e18193. doi:10.1371/journal.pone.0018193. pmid:21464895
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Prust ML,
    2. Banda CK,
    3. Nyirenda R, et al
    . Multi-month prescriptions, fast-track refills, and community ART groups: results from a process evaluation in Malawi on using differentiated models of care to achieve national HIV treatment goals. J Int AIDS Soc. 2017;20(Suppl 4):21650. doi:10.7448/ias.20.5.21650. pmid:28770594
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Deeks SG,
    2. Overbaugh J,
    3. Phillips A,
    4. Buchbinder S
    . HIV infection. Nat Rev Dis Primers. 2015;1:15035. doi:10.1038/nrdp.2015.35. pmid:27188527
    OpenUrlCrossRefPubMed
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Global Health: Science and Practice: 8 (2)
Global Health: Science and Practice
Vol. 8, No. 2
June 30, 2020
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Multimonth Dispensing of Antiretroviral Therapy Protects the Most Vulnerable From 2 Pandemics at Once
Ariana Moriah Traub, Temitayo Ifafore-Calfee, Benjamin Ryan Phelps
Global Health: Science and Practice Jun 2020, 8 (2) 176-177; DOI: 10.9745/GHSP-D-20-00160

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Multimonth Dispensing of Antiretroviral Therapy Protects the Most Vulnerable From 2 Pandemics at Once
Ariana Moriah Traub, Temitayo Ifafore-Calfee, Benjamin Ryan Phelps
Global Health: Science and Practice Jun 2020, 8 (2) 176-177; DOI: 10.9745/GHSP-D-20-00160
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