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SYNTHESIS
Open Access

Saving Mothers, Giving Life: It Takes a System to Save a Mother

Claudia Morrissey Conlon, Florina Serbanescu, Lawrence Marum, Jessica Healey, Jonathan LaBrecque, Reeti Hobson, Marta Levitt, Adeodata Kekitiinwa, Brenda Picho, Fatma Soud, Lauren Spigel, Mona Steffen, Jorge Velasco, Robert Cohen and William Weiss on behalf of the Saving Mothers, Giving Life Working Group
Global Health: Science and Practice March 2019, 7(Supplement 1):S6-S26; https://doi.org/10.9745/GHSP-D-18-00427
Claudia Morrissey Conlon
aBureau for Global Health, U.S. Agency for International Development, Washington, DC, USA.
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  • For correspondence: Cconlon{at}usaid.gov
Florina Serbanescu
bDivision of Reproductive Health, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
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Lawrence Marum
cCenters for Disease Control and Prevention, Lusaka, Zambia. Now retired.
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Jessica Healey
dU.S. Agency for International Development, Lusaka, Zambia. Now based in Monrovia, Liberia.
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Jonathan LaBrecque
aBureau for Global Health, U.S. Agency for International Development, Washington, DC, USA.
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Reeti Hobson
eBureau for Global Health, U.S. Agency for International Development, Washington, DC. Now with ICF, Rockville, MD, USA.
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Marta Levitt
fBureau for Global Health, U.S. Agency for International Development and RTI, Washington, DC, USA. Now with Palladium, Abuja, Nigeria.
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Adeodata Kekitiinwa
gBaylor College of Medicine Children's Foundation-Uganda, Kampala, Uganda.
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Brenda Picho
hInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
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Fatma Soud
iCenters for Disease Control and Prevention, Lusaka, Zambia. Now an independent consultant, Gainesville, FL, USA.
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Lauren Spigel
jICF, Fairfax, VA, USA. Now with Ariadne Labs, Boston, MA, USA.
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Mona Steffen
eBureau for Global Health, U.S. Agency for International Development, Washington, DC. Now with ICF, Rockville, MD, USA.
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Jorge Velasco
kU.S. Agency for International Development, Papua, New Guinea.
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Robert Cohen
aBureau for Global Health, U.S. Agency for International Development, Washington, DC, USA.
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William Weiss
aBureau for Global Health, U.S. Agency for International Development, Washington, DC, USA.
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  • FIGURE 1
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    FIGURE 1

    Saving Mothers, Giving Life Theory of Change Model

    Abbreviations: EmONC, emergency obstetric and newborn care; MCH, maternal and child health; MPDSR, maternal and perinatal death surveillance and response; MMR, maternal mortality ratio; NMR, neonatal mortality rate; PEPFAR, U.S. President's Emergency Plan for AIDS Relief; SMGL, Saving Mothers, Giving Life; USG, U.S. Government.

    Source: Adapted from Saving Mothers, Giving Life.57

  • FIGURE 2
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    FIGURE 2

    Saving Mothers, Giving Life-Designated Learning and Scale-Up Districts in Uganda and Zambia

    Source: Adapted from Saving Mothers, Giving Life.57

Tables

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    TABLE 1.

    Saving Mothers, Giving Life Supplement Articles

    Article No.Article Title
    1Saving Mothers, Giving Life: it takes a system to save a mother
    2Impact of the Saving Mothers, Giving Life approach on decreasing maternal and perinatal deaths in Uganda and Zambia
    3Addressing the first delay in Saving Mothers, Giving Life districts in Uganda and Zambia: approaches and results for increasing demand for facility delivery services
    4Addressing the second delay in Saving Mothers, Giving Life districts in Uganda and Zambia: reaching appropriate maternal care in a timely manner
    5Addressing the third delay in Saving Mothers, Giving Life districts in Uganda and Zambia: ensuring adequate and appropriate facility-based maternal and perinatal health care
    6The costs and cost-effectiveness of a district-strengthening strategy to mitigate the 3 delays to quality maternal health care: results from Uganda and Zambia
    7Saving lives together: a qualitative evaluation of the Saving Mothers, Giving Life public-private partnership
    8Community perceptions of a 3-delays model intervention: a qualitative evaluation of Saving Mothers, Giving Life in Zambia
    9Did the Saving Mothers, Giving Life initiative expand timely access to lifesaving care in Uganda? A spatial district-level analysis of travel time to emergency obstetric and newborn care
    10Saving Mothers, Giving Life approach for strengthening health systems to reduce maternal and newborn deaths in 7 scale-up districts in northern Uganda
    11Sustainability and scale of the Saving Mothers, Giving Life approach in Uganda and Zambia
    • View popup
    TABLE 2.

    Uganda and Zambia National-Level Indicators at the Start of the SMGL Initiative

    IndicatorUgandaZambia
    Maternal mortality ratio (per 100,000 live births)420a262a
    Deliveries in facilities57%b48%c
    Births by cesarean delivery5%b3%c
    Birth attended by skilled birth attendant57%b47%c
    Antenatal care coverage: at least 4 visits48%b60%c
    HIV prevalence among adults 15–497%d12%d
    Pregnant women with HIV receiving antiretroviral therapy61%d93%d
    Total fertility rate6.2b6.2c
    Modern contraceptive prevalence rate among all women 15–4921%b25%c
    Neonatal mortality rate (per 1,000 live births)27b34c
    • Abbreviation: SMGL, Saving Mothers, Giving Life.

    • ↵a 2010 data from Trends in Maternal Mortality: 1990 to 2015. Estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division (https://www.who.int/reproductivehealth/publications/monitoring/maternal-mortality-2015/en/).

    • ↵b 2011 data from Uganda Demographic and Health Survey 2011 (https://dhsprogram.com/pubs/pdf/FR264/FR264.pdf).

    • ↵c 2007 data from Zambia Demographic and Health Survey 2007 (https://www.dhsprogram.com/pubs/pdf/FR211/FR211[revised-05-12-2009].pdf).

    • ↵d 2011 data from UNAIDS AIDSinfo (http://aidsinfo.unaids.org/).

    • View popup
    TABLE 3.

    Emergency Obstetric and Newborn Care 9 Signal Functions

    Basic ServicesComprehensive Services
    1. Administer parenteral antibioticsPerform signal functions 1 through 7 plus:
    2. Administer uterotonic drugs (i.e., parenteral oxytocin, misoprostol)8. Surgery (cesarean delivery)
    3. Administer parenteral anticonvulsants for preeclampsia (i.e., magnesium sulfate)9. Blood transfusion
    4. Manually remove the placenta
    5. Remove retained products of conception (e.g., manual vacuum extraction, misoprostol, dilation and curettage)
    6. Perform assisted vaginal delivery (e.g., vacuum extraction, forceps delivery)
    7. Perform basic neonatal resuscitation (e.g., bag and mask)
    • Source: WHO, UNFPA, UNICEF, and Mailman School of Public Health.27

    • View popup
    TABLE 4.

    Key Results at Baseline and Phase 2 Endline in the SMGL Learning Districts

    SMGL IndicatorUgandaZambia
    2012 Baseline2016 Phase 2 Endline% Change Baseline to Phase 2Significancea2012 Baseline2016 Phase 2 Endline% Change Baseline to Phase 2Significancea
    GOAL
    Institutional MMR (per 100,000 live births)534300−44***370231−37.6***
    Community MMR (per 100,000 live births)452255−44***480284−40.8***
    Pre-discharge neonatal mortality rate (per 1,000 live births)8.47.6−10NS7.78.7+14NS
    Institutional perinatal mortality rate (per 1,000 births)39.334.4−13***37.928.2−26***
    Institutional total stillbirth rate (per 1,000 births)31.227.0−13***30.519.6−36***
    DEMAND
    Health facilities that report having a VHT (Uganda) or SMAG (Zambia) (%)1892+400***6493+46***
    Institutional delivery rate (%)4667+47***6390+44***
    Deliveries in EmONC facilities (%)2841+45***2629+12***
    Deliveries in lower-level facilities (health center II, III) (%)1726+48***3761+67***
    ACCESS
    Facilities that report having an associated mother's shelter (%)04NANA2949+69***
    Institutional deliveries supported by transport vouchers (%)624+277***Vouchers not provided in Zambia
    Number of BEmONC facilities where the 7 signal functions were performed in last 3 months39+200NA38+167NA
    Number of CEmONC facilities where the 9 signal functions were performed in last 3 months717+143NA45+25NA
    24/7 services at health centers (%)7589+18NS6596+41***
    QUALITY OF CARE
    Facilities reporting having performed newborn resuscitation in the previous 3 months (%)3488+155***2775+173***
    Facilities providing active management of the third stage of labor (%)7596+28***7296+33***
    Population-based cesarean delivery rate (%)5.39.0+71***2.74.8+79***
    Hospitals that currently have at least 1 long-acting family planning method (%)6394+51**5075+50NS
    Number of women receiving PMTCT treatment12622155+71NA9301036+11NA
    HEALTH SYSTEMS STRENGTHENING
    Hospitals conducting maternal death audits or reviews (%)3194+201***50100+100NA
    Health facilities that did not experience stock-outs of oxytocin in the last 12 months (%)5682+46***7575−0.4NS
    Health facilities that did not experience stock-outs of magnesium sulfate in the last 12 months (%)4864+34***2043+115***
    • Abbreviations: EmONC, emergency obstetric and newborn care; BEmONC, basic emergency obstetric and newborn care; CEmONC, comprehensive emergency obstetric and newborn care; MMR, maternal mortality ratio; NA, not applicable; NS, nonsignificant; SMAG, Safe Motherhood Action Group; VHT, Village Health Team; PMTCT, prevention of mother-to-child transmission of HIV.

    • ↵a *** P <.01; ** P <.05; * P <.10. NA in cases where significance testing was not warranted.

    • Source: Serbanescu et al.38

    • View popup
    TABLE 5.

    Select Indicators by Delivery Care Service Sector in Uganda, 2016

    IndicatorPublic-Sector FacilitiesPrivate-Sector FacilitiesSignificancea
    Maternal mortality ratio (per 100,000 live births)301295NS
    Direct case fatality rate1.81.5NS
    Perinatal mortality rate (per 1,000 births)34.036.4NS
    Intrapartum stillbirth rate (per 1,000 births)13.817.0**
    Total stillbirth rate (per 1,000 births)26.628.7NS
    Pre-discharge neonatal mortality rate (per 1,000 live births)7.67.9NS
    • Abbreviation: NS, nonsignificant.

    • ↵a ** P<.05.

    • Source: Serbanescu et al.38

Additional Files

  • Figures
  • Tables
  • Supplemental material

    Files in this Data Supplement:

    • The Savings Mothers, Giving Life Model - Text s01, DOCX
    • Saving Mothers, Giving Life Implementing Partners - Text s02, DOCX
    • Saving Mothers, Giving Life Routine Quarterly Indicators - Text s03, DOCX
    • Saving Mothers, Giving Life Special Studies Results - Text s04, DOCX
    • Comparison of SMGL Outcomes With DHS Surveys and UN Maternal Mortality Estimates - Text s05, DOCX
    • Strengthening the Safe Motherhood Ecosystem: A Case Study of Private Health Sector Mobilization in Uganda - Text s06, DOCX
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Global Health: Science and Practice: 7 (Supplement 1)
Global Health: Science and Practice
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March 11, 2019
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Saving Mothers, Giving Life: It Takes a System to Save a Mother
Claudia Morrissey Conlon, Florina Serbanescu, Lawrence Marum, Jessica Healey, Jonathan LaBrecque, Reeti Hobson, Marta Levitt, Adeodata Kekitiinwa, Brenda Picho, Fatma Soud, Lauren Spigel, Mona Steffen, Jorge Velasco, Robert Cohen, William Weiss
Global Health: Science and Practice Mar 2019, 7 (Supplement 1) S6-S26; DOI: 10.9745/GHSP-D-18-00427

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Saving Mothers, Giving Life: It Takes a System to Save a Mother
Claudia Morrissey Conlon, Florina Serbanescu, Lawrence Marum, Jessica Healey, Jonathan LaBrecque, Reeti Hobson, Marta Levitt, Adeodata Kekitiinwa, Brenda Picho, Fatma Soud, Lauren Spigel, Mona Steffen, Jorge Velasco, Robert Cohen, William Weiss
Global Health: Science and Practice Mar 2019, 7 (Supplement 1) S6-S26; DOI: 10.9745/GHSP-D-18-00427
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    • ABSTRACT
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  • Barriers and facilitators to facility-based delivery in rural Zambia: a qualitative study of womens perceptions after implementation of an improved maternity waiting homes intervention
  • If we build it, will they come? Results of a quasi-experimental study assessing the impact of maternity waiting homes on facility-based childbirth and maternity care in Zambia
  • Saving Mothers, Giving Life: Dont Neglect the Health Systems Element
  • Authors Response to "Saving Mothers, Giving Life: Dont Neglect the Health Systems Element"
  • Addressing the Second Delay in Saving Mothers, Giving Life Districts in Uganda and Zambia: Reaching Appropriate Maternal Care in a Timely Manner
  • The Costs and Cost-Effectiveness of a District-Strengthening Strategy to Mitigate the 3 Delays to Quality Maternal Health Care: Results From Uganda and Zambia
  • Sustainability and Scale of the Saving Mothers, Giving Life Approach in Uganda and Zambia
  • Saving Mothers, Giving Life: A Systems Approach to Reducing Maternal and Perinatal Deaths in Uganda and Zambia
  • Addressing the First Delay in Saving Mothers, Giving Life Districts in Uganda and Zambia: Approaches and Results for Increasing Demand for Facility Delivery Services
  • Addressing the Third Delay in Saving Mothers, Giving Life Districts in Uganda and Zambia: Ensuring Adequate and Appropriate Facility-Based Maternal and Perinatal Health Care
  • Saving Lives Together: A Qualitative Evaluation of the Saving Mothers, Giving Life Public-Private Partnership
  • Impact of the Saving Mothers, Giving Life Approach on Decreasing Maternal and Perinatal Deaths in Uganda and Zambia
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