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ORIGINAL ARTICLE
Open Access

Maternal and Neonatal Directed Assessment of Technologies (MANDATE): Methods and Assumptions for a Predictive Model for Maternal, Fetal, and Neonatal Mortality Interventions

Bonnie Jones-Hepler, Katelin Moran, Jennifer Griffin, Elizabeth M McClure, Doris Rouse, Carolina Barbosa, Emily MacGuire, Elizabeth Robbins and Robert L Goldenberg
Global Health: Science and Practice December 2017, 5(4):571-580; https://doi.org/10.9745/GHSP-D-16-00174
Bonnie Jones-Hepler
aRTI International, Research Triangle Park, NC, USA.
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  • For correspondence: bonniehepler@rti.org
Katelin Moran
aRTI International, Research Triangle Park, NC, USA.
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Jennifer Griffin
aRTI International, Research Triangle Park, NC, USA.
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Elizabeth M McClure
aRTI International, Research Triangle Park, NC, USA.
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Doris Rouse
aRTI International, Research Triangle Park, NC, USA.
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Carolina Barbosa
aRTI International, Research Triangle Park, NC, USA.
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Emily MacGuire
aRTI International, Research Triangle Park, NC, USA.
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Elizabeth Robbins
aRTI International, Research Triangle Park, NC, USA.
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Robert L Goldenberg
bDepartment of Obstetrics and Gynecology, Columbia University, New York, NY, USA.
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  • FIGURE 1.
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    FIGURE 1.

    Conditions Modeled in MANDATE

    Abbreviations: IUGR, intrauterine growth restriction; IVH, intraventricular hemorrhage; NEC, necrotizing enterocolitis; RDS, respiratory distress syndrome.

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    FIGURE 2.

    Decision Tree Modeling Methodology

    *Condition positive and negative is based on an “un-prevented” incidence rate (i.e., the proportion of the population who would get a condition if no preventive interventions were available).

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    TABLE.

    Similarities and Differences Between LiST and MANDATE

    LiSTMANDATE
    PurposeA Microsoft Windows-based software tool used to model the impact of scaling up health interventions aimed at reducing mortality and morbidity in mothers, newborns, and children under 5 years of ageA web-based, mathematical model designed to estimate maternal, fetal, and neonatal lives saved in sub-Saharan Africa and India
    Conditions IncludedMaternal, fetal, newborn, and child health interventions; malaria interventions; and HIV/AIDS interventionsMaternal, fetal, and neonatal health interventions, excluding HIV/AIDS; malaria is only evaluated based on deaths directly attributable to malaria
    Condition SpecificityCondition levelCondition and sub-condition level
    Intervention SpecificitySometimes packages interventions (e.g., active management of the third stage of labor)Generally unpackages interventions to focus on a specific component of an intervention (e.g., oxytocin, uterine massage, types of diagnostics)
    Intervention ConstructsCoverage, effectiveness; rates available for some interventions by setting, dependent on topicPenetration, utilization, efficacy, and transfer between care settings; rates available for each intervention by setting
    Type of SoftwareSpectrum software packageWeb-based
    Training and TutorialsUser manual, online tutorials, webinars, and technical assistanceOnline 15-minute tutorial and technical assistance
    Cost to UseFreeFree
    OutputsNumber of maternal and child (up to 5 years) deaths, mortality rates/ratios, deaths averted, intermediate outcomes (e.g., stunting, breastfeeding), and single- and multiple-country scenariosNumber of maternal, fetal, and newborn (up to 28 days) deaths, deaths averted, cases averted (e.g., postpartum hemorrhage, eclampsia), and single- and multiple-country scenarios
    • Abbreviations: LiST, Lives Saved Tool; MANDATE, Maternal and Neonatal Directed Assessment of Technologies.

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Global Health: Science and Practice: 5 (4)
Global Health: Science and Practice
Vol. 5, No. 4
December 28, 2017
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Maternal and Neonatal Directed Assessment of Technologies (MANDATE): Methods and Assumptions for a Predictive Model for Maternal, Fetal, and Neonatal Mortality Interventions
Bonnie Jones-Hepler, Katelin Moran, Jennifer Griffin, Elizabeth M McClure, Doris Rouse, Carolina Barbosa, Emily MacGuire, Elizabeth Robbins, Robert L Goldenberg
Global Health: Science and Practice Dec 2017, 5 (4) 571-580; DOI: 10.9745/GHSP-D-16-00174

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Maternal and Neonatal Directed Assessment of Technologies (MANDATE): Methods and Assumptions for a Predictive Model for Maternal, Fetal, and Neonatal Mortality Interventions
Bonnie Jones-Hepler, Katelin Moran, Jennifer Griffin, Elizabeth M McClure, Doris Rouse, Carolina Barbosa, Emily MacGuire, Elizabeth Robbins, Robert L Goldenberg
Global Health: Science and Practice Dec 2017, 5 (4) 571-580; DOI: 10.9745/GHSP-D-16-00174
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    • Maternal, Newborn, and Child Health
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