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ORIGINAL ARTICLE
Open Access

A Non–Gas-Based Cryotherapy System for the Treatment of Cervical Intraepithelial Neoplasia: A Mixed-Methods Approach for Initial Development and Testing

Miriam Cremer, Proma Paul, Katie Bergman, Michael Haas, Mauricio Maza, Albert Zevallos, Miguel Ossandon, Jillian D Garai and Jennifer L Winkler
Global Health: Science and Practice March 2017, 5(1):57-64; https://doi.org/10.9745/GHSP-D-16-00270
Miriam Cremer
aObstetrics, Gynecology & Women's Health Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
bBasic Health International, New York, NY, USA, and San Salvador, El Salvador.
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  • For correspondence: bhisubmissions{at}gmail.com
Proma Paul
bBasic Health International, New York, NY, USA, and San Salvador, El Salvador.
cUniversity of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
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Katie Bergman
bBasic Health International, New York, NY, USA, and San Salvador, El Salvador.
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Michael Haas
dCryoPen, Inc., Covington, LA, USA.
eDepartment of Family Medicine, Louisiana State University Health Science Center, New Orleans, LA, USA.
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Mauricio Maza
bBasic Health International, New York, NY, USA, and San Salvador, El Salvador.
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Albert Zevallos
fDepartment of Gynecology, National Institute for Neoplastic Diseases, Lima, Peru.
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Miguel Ossandon
gNational Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, USA.
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Jillian D Garai
bBasic Health International, New York, NY, USA, and San Salvador, El Salvador.
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Jennifer L Winkler
bBasic Health International, New York, NY, USA, and San Salvador, El Salvador.
hMel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
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  • FIGURE 1
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    FIGURE 1

    Standard CryoPen System Available in the United States (left) and the CryoPen System Adapted for Use in Low- and Middle-Income Countries (right)

Tables

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    TABLE 1.

    Bench Testing Results Comparing Heat Extraction Capabilities and Tip Temperatures of Standard Cryotherapy (Wallach LL100) Versus LMIC-Adapted CryoPen

    Wallach LL100 (n=15) Mean (SD)LMIC-Adapted CryoPen (n=15) Mean (SD)P Value
    Depth of freeze, mm7.14 (1.00)6.33 (1.21).06
    Lateral depth of freeze, mm7.86 (0.96)7.93 (1.32).88
    Diameter of freeze, mm29.37 (2.09)30.71 (3.61).23
    Mass of freeze ball, g7.71 (1.16)8.27 (1.33).22
    Average tip temperature in freeze cycle, °C−51.84 (4.99)−48.28 (6.37).10
    Minimum (coldest) tip temperature, °C−56.11 (4.19)−55.08 (7.42).64
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    TABLE 2.

    Preliminary LMIC-Adapted CryoPen Depth of Necrosis with a Single 5-Minute Freeze

    SampleMaximum Anterior Depth of Necrosis (mm)Maximum Posterior Depth of Necrosis (mm)
    14.03.9
    21.52.8
    36.16.0
    44.53.8
    54.53.9
    Mean4.124.08
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Global Health: Science and Practice: 5 (1)
Global Health: Science and Practice
Vol. 5, No. 1
March 24, 2017
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A Non–Gas-Based Cryotherapy System for the Treatment of Cervical Intraepithelial Neoplasia: A Mixed-Methods Approach for Initial Development and Testing
Miriam Cremer, Proma Paul, Katie Bergman, Michael Haas, Mauricio Maza, Albert Zevallos, Miguel Ossandon, Jillian D Garai, Jennifer L Winkler
Global Health: Science and Practice Mar 2017, 5 (1) 57-64; DOI: 10.9745/GHSP-D-16-00270

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A Non–Gas-Based Cryotherapy System for the Treatment of Cervical Intraepithelial Neoplasia: A Mixed-Methods Approach for Initial Development and Testing
Miriam Cremer, Proma Paul, Katie Bergman, Michael Haas, Mauricio Maza, Albert Zevallos, Miguel Ossandon, Jillian D Garai, Jennifer L Winkler
Global Health: Science and Practice Mar 2017, 5 (1) 57-64; DOI: 10.9745/GHSP-D-16-00270
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