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Original Articles
Open Access

Can traditional birth attendants be trained to accurately identify septic infants, initiate antibiotics, and refer in a rural African setting?

Christopher John Gill, William B MacLeod, Grace Phiri-Mazala, Nicholas G Guerina, Mark Mirochnick, Anna B Knapp and Davidson H Hamer
Global Health: Science and Practice August 2014, 2(3):318-327; https://doi.org/10.9745/GHSP-D-14-00045
Christopher John Gill
aBoston University School of Public Health, Boston, MA, USA
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  • For correspondence: cgill@bu.edu
William B MacLeod
aBoston University School of Public Health, Boston, MA, USA
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Grace Phiri-Mazala
bZambia Anglican Council, Lusaka, Zambia
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Nicholas G Guerina
cWomen and Neonates Hospital, Providence, Rhode Island, USA
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Mark Mirochnick
dBoston University School of Medicine, Boston, MA, USA
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Anna B Knapp
aBoston University School of Public Health, Boston, MA, USA
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Davidson H Hamer
aBoston University School of Public Health, Boston, MA, USA
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Figures

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  • Figure1
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    TBAs from Lufwanyama District, Zambia, attend a LUNESP training workshop to improve neonatal survival.

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    Figure.

    Data on Live-Born Neonates, June 2006–November 2008

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    Table 1. Baseline Maternal and Infant Characteristics Stratified by Infant Vital Status at Day 28 of Life
    CharacteristicInfant Survivors (n = 1,846)Infant Deaths (n = 43)All Neonates (N = 1,889)P Value
    Maternal Characteristics
    Age, y, mean (SD)25.3 (0.15)25.7 (1.27)25.3 (0.15).77
    Education (highest level attained), %.41
     None16.720.916.8
     Some primary69.258.168.9
     Some secondary13.820.914.0
     Some higher0.30.00.3
    Marital status, %.84
     Married89.486.089.3
     Widowed0.80.00.8
     Separated/divorced2.54.72.5
     Never married7.39.37.4
    No. of ANC visits attended, mean (SD)3.3 (0.03)3.2 (0.21)3.3 (0.03).67
    Receipt of treatment
     IPT of malaria with SP, %89.883.789.6.20
     Deworming treatments, %65.955.865.6.01
     Folic acid supplementation, %85.595.385.8.07
     Iron supplementation, %92.590.792.5.65
     Tetanus toxoid, %72.865.172.6.26
    Infant Characteristics
    Female, %50.532.650.1.02
    Gestational age at birth, weeks, mean (SD)38.0 (0.31)43.0 (2.19)38.1 (0.31).33
    Exclusively breastfed, %96.886.096.6<.001
    • Abbreviations: ANC, antenatal care; IPT, intermittent preventive therapy; SD, standard deviation; SP, sulfadoxine-pyrimethamine.

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    Table 2. Characteristics of the Intervention TBAs (N = 60)
    Characteristic
    Female, %100
    Age, y, mean (SD)49.2 (0.79)
    Years working as TBA, mean (SD)6.3 (0.81)
    Education
     Total years of education, mean (SD)6.3 (0.48)
     Never attended school, %5.0
     Primary education only, %78.3
    Main occupation, %
     TBA1.7
     Farmer98.3
    Source(s) of training prior to LUNESP,a %
     Trained by family11.5
     Trained by community, not family42.6
     Trained by Lufwanyama DHMT60.3
     Trained by another government organization33.3
     Trained by an NGO32.7
    • Abbreviations: DHMT, district health management team; LUNESP, Lufwanyama Neonatal Survival Project; NGO, nongovernmental organization; SD, standard deviation; TBA, traditional birth attendant.

    • ↵a TBAs often received training from more than 1 source.

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    Table 3. Sensitivity, Specificity, and Likelihood Ratios of Specified Reasons for Referral at Predicting a Fatal Outcome for the Referred Infant
    Reason for ReferralaTimes CitedPrevalence % (95% CI)Sensitivity % (95% CI)Specificity % (95% CI)LR+LR-
    Fever or felt hot8241.2 (34.3–48.4)15.0 (3.2–37.9)55.9 (48.3–63.3)0.31.5
    Had cough8040.4 (33.5–47.6)25.0 (8.7–49.1)57.9 (50.3–65.2)0.61.3
    Diarrhea157.6 (4.3–12.2)0.0 (0.0–16.1)91.6 (86.5–95.2)0.01.1
    Refusing to feed2412.1 (7.9–17.4)45.0 (23.1–68.5)91.6 (86.6–95.2)5.40.6
    Sleepy or difficult to arouse84.0 (1.8–7.8)20.0 (5.7–43.7)97.8 (94.3–99.4)9.10.8
    Floppy or poor muscle tone189.1 (5.5–14.0)25.0 (8.7–49.1)92.7 (87.8–96.1)3.40.8
    Not making urine2231.9 (21.2–44.2)57.1 (18.4–90.1)71.0 (58.1–81.8)2.00.6
    Convulsions, fits, or seizures84.1 (1.8–7.8)15.0 (3.2–37.9)97.2 (93.5–99.1)5.40.9
    Difficulty breathing5226.4 (20.4–33.1)65.0 (40.8–84.6)78 (71.1–83.8)3.00.4
    Rapid breathing52.5 (0.8–5.8)10.0 (1.2–31.7)98.3 (95.1–99.6)5.90.9
    Chest wall in-drawing10.5 (0.0–2.8)0.0 (0.0–16.1)99.4 (96.9–100.0)0.01.0
    Skin pustules or red rash63.0 (1.1–6.5)0.0 (0.0–39.0)96.6 (92.8–98.7)0.01.0
    Infected umbilicus31.5 (0.3–4.4)5.0 (0.1–24.9)98.9 (96–99.9)4.51.0
    Bulging fontanel52.5 (0.8–5.8)10.0 (1.2–31.7)98.3 (95.1–99.6)5.90.9
    TBA thought baby appeared ill16482.8 (76.8–87.8)95.0 (75.1–99.9)18.5 (13.1–25.0)1.20.3
    Mother thought baby appeared ill16080.8 (74.6–86.0)80.0 (56.3–94.3)19.1 (13.6–25.7)1.01.0
    Otherb62NANANANANA
    No reason cited8NANANANANA
    • Abbreviations: CI, confidence interval; LR+ and LR−, positive and negative likelihood ratios (clinically relevant LR+ and LR− values are in bold); NA, not applicable.

    • ↵a TBAs were free to specify more than 1 reason for a given referral, so the total number of reasons for referral exceeds the number of neonates who were referred (208).

    • ↵b Among the “other” reasons cited, those cited more than once included 12 citations for abdominal complaints (not making stool, swollen or tender belly, or diarrhea); 8 citations for inconsolable crying; 6 because the baby had been resuscitated at birth (all of which occurred during the first follow-up visit during week 1); 6 for skin rashes or sores; 4 for congenital defects or prematurity; 3 for respiratory complaints; and 3 for eye infections or discharge.

    • View popup
    Table 4. Survival of Neonates Stratified by the Subjective Severity of Illness Rating Assigned by the Referring TBA (N = 185)a
    OutcomeSeverity Rating, n/N (%)
    Not sickModerately sickExtremely sick
    Died3/49 (6.1%)6/113 (5.3%)11/23 (47.8%)
    Survived46/49 (93.9%)107/113 (94.7%)12/23 (52.2%)
    Total49/185 (26.5%)113/185 (61.1%)23/185 (12.4%)b
    • Abbreviation: TBA, traditional birth attendant.

    • ↵a A total of 208 neonates were referred; TBAs provided a severity assessment for 185 of the 208 neonates (88.9%). Data for analysis relates only to the final referral if the infant was referred more than once given that an infant referred twice could not possibly have died during the first referral event.

    • ↵b Chi square = 37.3 with 2 df, P< .001; comparing “extremely sick” vs. combined (“not sick” and “moderately sick”), RR of fatal outcome = 8.61, 95% CI = 4.0–18.5.

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Global Health: Science and Practice: 2 (3)
Global Health: Science and Practice
Vol. 2, No. 3
August 01, 2014
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Can traditional birth attendants be trained to accurately identify septic infants, initiate antibiotics, and refer in a rural African setting?
Christopher John Gill, William B MacLeod, Grace Phiri-Mazala, Nicholas G Guerina, Mark Mirochnick, Anna B Knapp, Davidson H Hamer
Global Health: Science and Practice Aug 2014, 2 (3) 318-327; DOI: 10.9745/GHSP-D-14-00045

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Can traditional birth attendants be trained to accurately identify septic infants, initiate antibiotics, and refer in a rural African setting?
Christopher John Gill, William B MacLeod, Grace Phiri-Mazala, Nicholas G Guerina, Mark Mirochnick, Anna B Knapp, Davidson H Hamer
Global Health: Science and Practice Aug 2014, 2 (3) 318-327; DOI: 10.9745/GHSP-D-14-00045
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