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ORIGINAL ARTICLE
Open Access

Development and Piloting of Implementation Strategies to Support Delivery of a Clinical Intervention for Postpartum Hemorrhage in Four sub-Saharan Africa Countries

Gillian Forbes, Shahinoor Akter, Suellen Miller, Hadiza Galadanci, Zahida Qureshi, Fadhlun Alwy Al-beity, G. Justus Hofmeyr, Neil Moran, Sue Fawcus, Mandisa Singata-Madliki, Aminu Ado Wakili, Taiwo Gboluwaga Amole, Baba Maiyaki Musa, Faisal Dankishiya, Adamu Abdullahi Atterwahmie, Abubakar Shehu Muhammad, John Ekweani, Emily Nzeribe, Alfred Osoti, George Gwako, Jenipher Okore, Amani Kikula, Emmy Metta, Ard Mwampashi, Cherrie Evans, Kristie-Marie Mammoliti, Adam Devall, Arri Coomarasamy, Ioannis Gallos, Olufemi T. Oladapo, Meghan A. Bohren and Fabiana Lorencatto
Global Health: Science and Practice October 2024, 12(5):e2300387; https://doi.org/10.9745/GHSP-D-23-00387
Gillian Forbes
aCentre for Behaviour Change, University College London, London, United Kingdom.
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Shahinoor Akter
bGender and Women’s Health Unit, Nossal Institute for Global Health, School of Population and Global Health, University of Melbourne, Melbourne, Australia.
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Suellen Miller
cDepartment of Obstetrics, Gynaecology, and Reproductive Sciences, School of Medicine, University of California, San Francisco, CA, USA.
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Hadiza Galadanci
dAfrica Center of Excellence for Population Health and Policy, Bayero University, Kano, Nigeria.
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Zahida Qureshi
eDepartment of Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya.
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Fadhlun Alwy Al-beity
fDepartment of Obstetrics and Gynecology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
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G. Justus Hofmeyr
gEffective Care Research Unit, University of the Witwatersrand and Walter Sisulu University, Johannesburg, South Africa.
hDepartment of Obstetrics and Gynecology, University of Botswana, Gaborone, Botswana.
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Neil Moran
iKwaZulu-Natal Department of Health; and Department of Obstetrics and Gynaecology, School of Clinical Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
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Sue Fawcus
jDepartment of Obstetrics and Gynaecology, University of Cape Town, Cape Town, South Africa.
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Mandisa Singata-Madliki
gEffective Care Research Unit, University of the Witwatersrand and Walter Sisulu University, Johannesburg, South Africa.
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Aminu Ado Wakili
dAfrica Center of Excellence for Population Health and Policy, Bayero University, Kano, Nigeria.
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Taiwo Gboluwaga Amole
dAfrica Center of Excellence for Population Health and Policy, Bayero University, Kano, Nigeria.
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Baba Maiyaki Musa
dAfrica Center of Excellence for Population Health and Policy, Bayero University, Kano, Nigeria.
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Faisal Dankishiya
dAfrica Center of Excellence for Population Health and Policy, Bayero University, Kano, Nigeria.
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Adamu Abdullahi Atterwahmie
kFederal Medical Center, Nguru, Nigeria.
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Abubakar Shehu Muhammad
lAbubakar Tafawa Belawa University Teaching Hospital, Bauch, Nigeria.
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John Ekweani
mFederal Medical Center, Abuja, Nigeria.
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Emily Nzeribe
nFederal Medical Center, Owerri, Nigeria.
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Alfred Osoti
eDepartment of Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya.
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George Gwako
eDepartment of Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya.
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Jenipher Okore
eDepartment of Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya.
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Amani Kikula
fDepartment of Obstetrics and Gynecology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
oDepartment of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.
pGlobal Health Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
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Emmy Metta
qDepartment of Behavioural Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
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Ard Mwampashi
fDepartment of Obstetrics and Gynecology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
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Cherrie Evans
rMaternal and Newborn Health Unit, Technical Leadership and Innovation, Jhpiego, Baltimore, MD, USA.
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Kristie-Marie Mammoliti
sWHO Collaborating Centre on Global Women’s Health, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
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Adam Devall
sWHO Collaborating Centre on Global Women’s Health, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
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Arri Coomarasamy
sWHO Collaborating Centre on Global Women’s Health, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
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Ioannis Gallos
tUNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
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Olufemi T. Oladapo
tUNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
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Meghan A. Bohren
bGender and Women’s Health Unit, Nossal Institute for Global Health, School of Population and Global Health, University of Melbourne, Melbourne, Australia.
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Fabiana Lorencatto
aCentre for Behaviour Change, University College London, London, United Kingdom.
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  • For correspondence: f.lorencatto{at}ucl.ac.uk
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Key Findings

  • Before introducing a new clinical intervention to improve the early detection of postpartum hemorrhage, we used multiple data collection methods (interviews, surveys, observations, and stakeholder workshops) to have a broad and in-depth understanding of key implementation issues, which included staff and drug shortages, limited in-service training, and different attitudes of staff toward adopting a new clinical intervention despite its perceived benefits.

  • Conducting a pilot study with a process evaluation identified required modifications to implementation strategies before a larger randomized trial.

  • Delivery of a new clinical care bundle and supporting implementation strategies for earlier postpartum hemorrhage detection and management were largely acceptable and feasible.

  • However, fidelity was initially more challenging for staff when it required significant changes to existing practices for detection and management of postpartum hemorrhage.

Key Implications

  • Findings from the formative research helped to identify potential implementation issues and enabled refinement and increased preparedness before a larger-scale randomized trial.

  • Collaborations across research disciplines and with health care providers enhance the development, design, and dissemination of new clinical interventions and their implementation strategies.

ABSTRACT

Introduction:

Postpartum hemorrhage (PPH) remains the leading cause of maternal mortality. A new clinical intervention (E-MOTIVE) holds the potential to improve early PPH detection and management. We aimed to develop and pilot implementation strategies to support uptake of this intervention in Kenya, Nigeria, South Africa, and Tanzania.

Methods:

Implementation strategy development: We triangulated findings from qualitative interviews, surveys and a qualitative evidence synthesis to identify current PPH care practices and influences on future intervention implementation. We mapped influences using implementation science frameworks to identify candidate implementation strategies before presenting these at stakeholder consultation and design workshops to discuss feasibility, acceptability, and local adaptations. Piloting: The intervention and implementation strategies were piloted in 12 health facilities (3 per country) over 3 months. Interviews (n=58), case report forms (n=1,269), and direct observations (18 vaginal births, 7 PPHs) were used to assess feasibility, acceptability, and fidelity.

Results:

Implementation strategy development: Key influences included shortages of drugs, supplies, and staff, limited in-service training, and perceived benefits of the intervention (e.g., more accurate PPH detection and reduced PPH mortality). Proposed implementation strategies included a PPH trolley, on-site simulation-based training, champions, and audit and feedback. Country-specific adaptations included merging the E-MOTIVE intervention with national maternal health trainings, adapting local PPH protocols, and PPH trollies depending on staff needs. Piloting: Intervention and implementation strategy fidelity differed within and across countries. Calibrated drapes resulted in earlier and more accurate PPH detection but were not consistently used at the start. Implementation strategies were feasible to deliver; however, some instances of limited use were observed (e.g., PPH trolley and skills practice after training).

Conclusion:

Systematic intervention development, piloting, and process evaluation helped identify initial challenges related to intervention fidelity, which were addressed ahead of a larger-scale effectiveness evaluation. This has helped maximize the internal validity of the trial.

  • Received: September 12, 2023.
  • Accepted: August 13, 2024.
  • Published: October 29, 2024.
  • © Forbes et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly cited. To view a copy of the license, visit https://creativecommons.org/licenses/by/4.0/. When linking to this article, please use the following permanent link: https://doi.org/10.9745/GHSP-D-23-00387

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Global Health: Science and Practice: 12 (5)
Global Health: Science and Practice
Vol. 12, No. 5
October 29, 2024
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Development and Piloting of Implementation Strategies to Support Delivery of a Clinical Intervention for Postpartum Hemorrhage in Four sub-Saharan Africa Countries
Gillian Forbes, Shahinoor Akter, Suellen Miller, Hadiza Galadanci, Zahida Qureshi, Fadhlun Alwy Al-beity, G. Justus Hofmeyr, Neil Moran, Sue Fawcus, Mandisa Singata-Madliki, Aminu Ado Wakili, Taiwo Gboluwaga Amole, Baba Maiyaki Musa, Faisal Dankishiya, Adamu Abdullahi Atterwahmie, Abubakar Shehu Muhammad, John Ekweani, Emily Nzeribe, Alfred Osoti, George Gwako, Jenipher Okore, Amani Kikula, Emmy Metta, Ard Mwampashi, Cherrie Evans, Kristie-Marie Mammoliti, Adam Devall, Arri Coomarasamy, Ioannis Gallos, Olufemi T. Oladapo, Meghan A. Bohren, Fabiana Lorencatto
Global Health: Science and Practice Oct 2024, 12 (5) e2300387; DOI: 10.9745/GHSP-D-23-00387

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Development and Piloting of Implementation Strategies to Support Delivery of a Clinical Intervention for Postpartum Hemorrhage in Four sub-Saharan Africa Countries
Gillian Forbes, Shahinoor Akter, Suellen Miller, Hadiza Galadanci, Zahida Qureshi, Fadhlun Alwy Al-beity, G. Justus Hofmeyr, Neil Moran, Sue Fawcus, Mandisa Singata-Madliki, Aminu Ado Wakili, Taiwo Gboluwaga Amole, Baba Maiyaki Musa, Faisal Dankishiya, Adamu Abdullahi Atterwahmie, Abubakar Shehu Muhammad, John Ekweani, Emily Nzeribe, Alfred Osoti, George Gwako, Jenipher Okore, Amani Kikula, Emmy Metta, Ard Mwampashi, Cherrie Evans, Kristie-Marie Mammoliti, Adam Devall, Arri Coomarasamy, Ioannis Gallos, Olufemi T. Oladapo, Meghan A. Bohren, Fabiana Lorencatto
Global Health: Science and Practice Oct 2024, 12 (5) e2300387; DOI: 10.9745/GHSP-D-23-00387
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