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TECHNICAL NOTE
Open Access

Digitalizing Clinical Guidelines: Experiences in the Development of Clinical Decision Support Algorithms for Management of Childhood Illness in Resource-Constrained Settings

Fenella Beynon, Frédérique Guérin, Riccardo Lampariello, Torsten Schmitz, Rainer Tan, Natschja Ratanaprayul, Tigest Tamrat, Karell G. Pellé, Gaud Catho, Kristina Keitel, Irene Masanja and Clotilde Rambaud-Althaus
Global Health: Science and Practice August 2023, 11(4):e2200439; https://doi.org/10.9745/GHSP-D-22-00439
Fenella Beynon
aSwiss Tropical and Public Health Institute, Basel, Switzerland.
bUniversity of Basel, Basel, Switzerland.
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Frédérique Guérin
cGeneva Science-Policy Interface, University of Geneva, Switzerland.
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Riccardo Lampariello
dTerre des Hommes, Lausanne, Switzerland.
eD-tree, USA.
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Torsten Schmitz
aSwiss Tropical and Public Health Institute, Basel, Switzerland.
bUniversity of Basel, Basel, Switzerland.
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Rainer Tan
aSwiss Tropical and Public Health Institute, Basel, Switzerland.
bUniversity of Basel, Basel, Switzerland.
fDigital and Global Health Unit, Unisanté, Center for Primary Care and Public Health, Lausanne, Switzerland.
gIfakara Health Institute, Dar es Salaam, Tanzania.
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Natschja Ratanaprayul
hDepartment of Digital Health and Innovations, World Health Organization, Geneva, Switzerland.
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Tigest Tamrat
iUNDP/UNFPA/UNICEF/World Bank Special Program of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
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Karell G. Pellé
jFIND, Geneva, Switzerland.
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Gaud Catho
kDivision of Infectious Diseases, Geneva University Hospital and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
lGlobal Health Institute, University of Geneva, Geneva, Switzerland.
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Kristina Keitel
aSwiss Tropical and Public Health Institute, Basel, Switzerland.
bUniversity of Basel, Basel, Switzerland.
mDepartment of Pediatric Emergency Medicine, Department of Pediatrics, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
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Irene Masanja
gIfakara Health Institute, Dar es Salaam, Tanzania.
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Clotilde Rambaud-Althaus
nMédecins Sans Frontières Switzerland, Operational Center Geneva, Geneva, Switzerland.
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Figures & Tables

Figures

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  • FIGURE 1
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    FIGURE 1

    Consultation Workflows: A. Representation of the WHO IMCI Chart Booklet workflowa,b; B. Generic clinical consultation workflowc; C. Hybrid workflow combining elements of the symptom-driven workflow (A) With natural consultation process (B)d

    Abbreviations: IMCI, Integrated Management of Childhood Illness; VSD, very severe disease; WHO, World Health Organization.

    a Integrated eDiagnosis Approach follows a similar workflow but also includes a registration/triage step in which temperature, anthropometric measurements, and malaria rapid diagnostic test (if fever) are conducted, with this information being entered later in the workflow.

    b Prevention: includes immunization, vitamin A, deworming, nutrition counseling, TB, HIV, etc.

    c Electronic Point-of-Care Test Plus follows a similar workflow.

    d Algorithm for the Management of Childhood Illnesses and MSFeCARE-Ped implemented workflows similar to this.

  • FIGURE 2
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    FIGURE 2

    High-Level Overview of Processes Involved in the Development and Implementation of Clinical Decision Support Systems, With Feedback Loops Between Stages

Tables

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    TABLE 1.

    Clinical Decision Support Systems for Pediatric Primary Care in Resource-Constrained Settings Selected for Comparative Assessment

    CDSS and Software; PlatformDeveloping Agency and CollaboratorsIntervention TypeCountries, Dates Implemented, and Implementation Scale

    IeDA;

    Commcare/Dimagi

    Terre des hommes

    MOHs, LSHTM, Centre Muraz, UNIGE, FIND, WHO, Tableau, Cloudera, ITU, IPE Global

    QI/HSS/Research

    Since 2010, >20 million consultations;

    • Burkina Faso, 2010, 1844 HF

    • Mali, 2017, 50 HF

    • Niger, 2019, 2 HF

    • India, 2020, 296 HF

    • Guinea, 2022, 15 HF

    ALMANACH;

    Commcare/Dimagi

    SwissTPH and IHI

    MOHs, ICRC, Adamawa SPHCDA, Somali Red Crescent Society

    QI in humanitarian settings/HSS;

    Tanzania: Research pilot

    Since 2015, >535,000 consultations;

    • Tanzania, 2011–2012, 6 HF (research)

    • Afghanistan, 2015–2017, 3 HF

    • Nigeria, 2016–ongoing, 412 HF

    • Somalia, 2020–ongoing, 23–28 HF

    • Libya, 2022–ongoing, 6–28 HF

    MSFeCARE-Ped;

    Logiak/Things Prime

    MSF Switzerland

    MOHs

    QI in humanitarian settings

    MSF projects 2017–ongoing in 16 projects, 39 HF, >410,000 consultations:

    • Central African Republic

    • Democratic Republic of Congo

    • Kenya

    • Mali

    • Mozambique

    • Niger

    • South Sudan

    • (historically Chad, Nigeria, and Tanzania)

    ePOCT;

    Mangologic

    SwissTPH

    IHI, MOH

    Research/PilotTanzania 2014–2016; 9 HF; 1,586 consultations

    ePOCT+;

    medAL-creator and medAL-reader/Wavemind

    SwissTPH and Unisanté

    MOHs, PATH, IHI, KGMU, UCAD, UON, IHI, NIMR-MMRC, MOHs, EPFL, FIND

    QI/HSS/Research

    2019–ongoing; >310,000 consultations in large-scale research studies:

    TIMCI project in

    • India, 9 HF pilot

    • Kenya, 60 HF

    • Senegal, 60 HF

    • Tanzania, 24 HFDynamic project in

    • Tanzania, 60 HF

    • Rwanda, 39 HF

    • Abbreviations: CDSS, clinical decision support system; EPFL, École polytechnique fédérale de Lausanne; ePOCT, electronic point-of-care test; FIND, the global alliance for diagnostics; HF, health facilities; HSS, health systems strengthening; ICRC, International Committee of the Red Cross; IHI, Ifakara Health Institute; ITU, International Telecommunication Union; KGMU, King George’s Medical University, Lucknow; LSHTM, London School of Hygiene and Tropical Medicine; MOH, ministry of health; MSF, Médecins Sans Frontières; NIMR-MMRC, National Institute of Medical Research Mbeya Medical Research Centre; QI, quality (of care) improvement; RCT, randomized controlled trial; SDC, Swiss Agency for Development and Cooperation; SPHCDA, State Primary Health Care Development Agency; SwissTPH, Swiss Tropical and Public Health Institute; TIMCI, Tools for Integrated Management of Childhood Illness; UCAD, Université Cheikh Anta Diop de Dakar; UON, University of Nairobi; UNIGE, University of Geneva; WHO, World Health Organization.

    • View popup
    TABLE 2.

    Comparison of Scope of Clinical Decision Support Systems to IMCI Guidelines

    IMCIIeDAALMANACHMSF-eCAREePOCT+
    Age0–2 monthsXXPlannedPlannedX
    2–59 monthsXXXXX
    5–14 yearsSome countries
    Main symptomsDanger signsXXXXX
    Cough/difficulty breathingXXXXX
    DiarrheaXXXXX
    Fever (malaria, measles)XXXXX
    Ear problemXXXXX
    Skin problemHIV-relatedHIV-relatedXXX
    Fever (non-malaria)MentionedMentionedXXX
    Sore throatXXSome countries
    Mouth problemXSome countries
    Eye problemXSome countries
    Abdominal painXSome countries
    TraumaSome countries
    Systematic screening and managementAnemiaXXXXX
    MalnutritionXXXXX
    HIVXXXXSome countries
    TBPilotX
    PreventionVitamin AXXXX
    DewormingXXXX
    VaccinationXXXXX
    FeedingXXXX
    Point-of-care and lab testsMalariaXXXXX
    HIVXXXSome countries
    HemoglobinXOptionalSome countries
    UrineXXSome countries
    Pulse oximetryPilotOptionalX
    GlucoseXOptionalSome countries
    Stool microscopyXSome countries
    Strep-AX
    DenguePilotSome countries
    TyphoidXSome countries
    C-reactive proteinSome countries
    • Abbreviations: ALMANACH, Algorithm for the Management of Childhood Illnesses; ePOCT+, Electronic Point-of-Care Test Plus; IeDA, Integrated eDiagnosis Approach; IMCI, Integrated Management of Childhood Illness.

    • View popup
    TABLE 3.

    Sources or Reference Documents Used in the Adaptation and/or Development of New Content and Content-Validation Committee

    Source(s)RationaleCDSS
    IMCI guidelines
    • WHO generic and/or national IMCI guidelines to reflect country specific adaptations.

    • May involve updates based on national/international guidelines (e.g., national pneumonia guidelines may have been updated more recently than IMCI).

    All
    Other national or international guidelines (e.g., standard treatment guidelines, formularies, disease-specific guidelines for malaria, TB, HIV, etc.)
    • To extend scope (relative to IMCI) by incorporating information from various guidelines relevant to the diagnosis and management of children in primary care (that health workers are expected to implement at a country level) or to reflect most up-to-date relevant guidance not yet incorporated into national guidelines due to long guideline update cycles (e.g., WHO young infant guidelines).

    All
    Existing or newly conducted evidence syntheses (systematic reviews/meta-analyses)
    • To implement relevant guidance not yet incorporated into national or international guidelines (due to long guideline update cycles), particularly if extending scope.

    ALMANACH, MSFeCARE-Ped, ePOCT+
    Epidemiological data (surveillance/research)
    • To target focus for additional scope/content (on conditions with significant morbidity or mortality).

    • To incorporate flexibility within the algorithm (e.g., diagnostic and treatment advice differing based on location of facilities in high/low prevalence areas for diseases such as malaria).

    MSFeCARE-Ped, ePOCT+,

    IeDA

    Existing clinical algorithm
    • To use work already conducted on translating narrative guidance into decision logic, including updates that may have been made over time based on implementation experience or novel diagnostic/treatment approaches that may have been evaluated elsewhere.

    All
    Expert opinion (national or international panel)
    • To advise which source documents (guidelines or other evidence) should be used as a basis for the algorithm.

    • To advise/review/validate interpretation of narrative guidelines/evidence translation to human-readable algorithm.

    All
    • Abbreviations: ALMANACH, Algorithm for the Management of Childhood Illnesses; ePOCT+, Electronic Point-of-Care Test Plus; IeDA, Integrated eDiagnosis Approach; IMCI, Integrated Management of Childhood Illness; WHO, World Health Organization.

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Global Health: Science and Practice: 11 (4)
Global Health: Science and Practice
Vol. 11, No. 4
August 28, 2023
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Digitalizing Clinical Guidelines: Experiences in the Development of Clinical Decision Support Algorithms for Management of Childhood Illness in Resource-Constrained Settings
Fenella Beynon, Frédérique Guérin, Riccardo Lampariello, Torsten Schmitz, Rainer Tan, Natschja Ratanaprayul, Tigest Tamrat, Karell G. Pellé, Gaud Catho, Kristina Keitel, Irene Masanja, Clotilde Rambaud-Althaus
Global Health: Science and Practice Aug 2023, 11 (4) e2200439; DOI: 10.9745/GHSP-D-22-00439

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Digitalizing Clinical Guidelines: Experiences in the Development of Clinical Decision Support Algorithms for Management of Childhood Illness in Resource-Constrained Settings
Fenella Beynon, Frédérique Guérin, Riccardo Lampariello, Torsten Schmitz, Rainer Tan, Natschja Ratanaprayul, Tigest Tamrat, Karell G. Pellé, Gaud Catho, Kristina Keitel, Irene Masanja, Clotilde Rambaud-Althaus
Global Health: Science and Practice Aug 2023, 11 (4) e2200439; DOI: 10.9745/GHSP-D-22-00439
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  • Article
    • ABSTRACT
    • INTRODUCTION
    • CDSS OBJECTIVES AND CONTEXTS OF DEVELOPMENT AND IMPLEMENTATION
    • IDENTIFIED ADAPTATIONS FROM THE IMCI CHART BOOKLET
    • COMPARISON OF PROCESSES FOR CDSS DEVELOPMENT
    • DISCUSSION
    • CONCLUSION
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