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ORIGINAL ARTICLE
Open Access

Evaluation of a Depression Intervention in People With HIV and/or TB in Eswatini Primary Care Facilities: Implications for Southern Africa

Nina Putnis, Nick Riches, Archibald Nyamayaro, Darah Boucher, Rebecca King, Ian F. Walker, Alett Burger, Paul Southworth, Violet Mwanjali and John Walley
Global Health: Science and Practice April 2023, 11(2):e2200016; https://doi.org/10.9745/GHSP-D-22-00016
Nina Putnis
aNuffield Institute of International Health and Development, University of Leeds, Leeds, United Kingdom.
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Nick Riches
aNuffield Institute of International Health and Development, University of Leeds, Leeds, United Kingdom.
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Archibald Nyamayaro
aNuffield Institute of International Health and Development, University of Leeds, Leeds, United Kingdom.
bGood Shepherd Hospital, Siteki, Eswatini.
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Darah Boucher
cLubombo Health Research Unit, Siteki, Eswatini.
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Rebecca King
aNuffield Institute of International Health and Development, University of Leeds, Leeds, United Kingdom.
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Ian F. Walker
aNuffield Institute of International Health and Development, University of Leeds, Leeds, United Kingdom.
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Alett Burger
cLubombo Health Research Unit, Siteki, Eswatini.
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Paul Southworth
aNuffield Institute of International Health and Development, University of Leeds, Leeds, United Kingdom.
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Violet Mwanjali
dNational Psychiatric Referral Hospital, Manzini, Eswatini.
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John Walley
aNuffield Institute of International Health and Development, University of Leeds, Leeds, United Kingdom.
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Key Findings

  • Integrating care for chronic diseases, including mental health conditions, is a critical yet challenging element of universal health coverage goals, especially in low- and middle-income countries. The simple intervention for depression and anxiety, based on behavioral methodologies, supports people living with HIV and/or TB with comorbid depression or anxiety.

  • This pilot service evaluation presents real-life findings, with a focus on acceptability and feasibility, demonstrating issues around feasibility and the capacity of nonspecialist nursing staff to undertake additional mental health counseling without explicit support and resources, including time. It demonstrates acceptability among staff and patients.

Key Implications

  • Policymakers, health systems leaders, and health service staff should recognize the importance of integrated care, especially neglected mental health care, and advocate for dedicated resources, time, and capacity of health workers to take on this additional role.

  • Meaningful consultation with the health workforce is a critical element of service development.

ABSTRACT

Introduction:

Depression associated with chronic illnesses is common in Southern Africa, yet there are major treatment gaps. This study assesses the feasibility and acceptability of the Healthy Activity Program intervention for depression among people with HIV and/or TB. The intervention involves training nonspecialist nurses in depression, including identification, counseling based on behavioral activation theory, and structured referral.

Methods:

This is a mixed methods evaluation of a pilot counseling service integrated within routine HIV and TB care from 2018 to 2019. Participants included people living with HIV and/or patients with TB in rural Eswatini.

Results:

A total of 324 people living with HIV and/or TB were screened for depression, with 19% (62/324) screening positive. The median number of sessions attended was 3 (interquartile range: 1–5), with 16/60 (26%) attending the minimum 5 sessions. Qualitative results indicated acceptability, but there were concerns about feasibility.

Conclusions:

The Healthy Activity Program is a promising option to manage the treatment gap for depression in people with HIV and/or TB. However, task-shifting to nonspecialist health care professionals without increasing staff capacity is a barrier to implementation. Realistic and pragmatic assessments of capacity and workforce are essential.

INTRODUCTION

Depression is the most common mental health condition worldwide, including in sub-Saharan Africa (SSA).1 Estimated prevalence of mental disorders in low- and middle-income countries is high, yet data are scant, and mental health systems are limited and underresourced.2–4 The World Health Organization’s Mental Health Gap Action Program outlines that the majority of people living with mental health conditions in low- and middle-income countries cannot access psychological care.5 Providing basic care for depression in nonspecialist primary care is a global priority.6,7 Evidence from Africa about how best to provide this is scarce.8

HIV and TB have a profound impact on health in SSA. Approximately 800,000 new HIV infections were diagnosed in 2017 in Eastern/Southern Africa, bringing the total number of people living with HIV (PLHIV) in this region to an estimated 20.6 million.9 In 2021, TB incidence in the World Health Organization Africa Region was 2.4 million.10 In 2020, 73% of global HIV-associated TB infections occurred there.11

HIV and TB are risk factors for depression and anxiety.12,13 It is estimated that more than one-third of PLHIV in SSA experience depression.13,14 Stigma and discrimination, family life, and financial impacts intersect with sequelae of disease and treatment, posing substantial risks to mental health.13,15 These mental health conditions are poorly recognized and vastly undertreated.12,13,16,17

Treatment adherence, which is vital to good HIV and TB outcomes, involves complex and multidimensional factors and is highly linked to social pressures and mental health. Successive systematic reviews have found lower adherence to antiretroviral medication in those living with depression.18–20 It is clear that providing holistic care for people living with HIV and TB must include mental health support. Integrating high-quality, culturally sensitive care within routine health care systems has the potential to improve both mental health outcomes and HIV and TB treatment adherence.21,22 Integration of HIV, TB, and mental health into primary care is critical to improving access to this holistic care.23,24

Treatment adherence is vital to good HIV and TB outcomes and is highly linked to mental health. Adequate care for people living with HIV and/or TB must include mental health support.

Eswatini is a small country in southern Africa with a population of around 1 million.25 The Lubombo region is predominately rural and poverty is prevalent. Despite middle-income status, Eswatini is an economically unequal country, with more than 60% of the population living below the national poverty line.26,27 It has one of the highest HIV rates in the world at 27.4% of adults, with the highest rates in Lubombo.28,29 TB rates are high, with more than 4,200 new cases reported nationally in 2017, an estimated 70% in PLHIV.30 Public mental health care is centralized in Eswatini, with 1 psychiatrist and (at the time of this study) 2 psychologists working in 1 public National Psychiatric Referral Hospital, which is too far and too expensive to travel for many people, especially from rural Lubombo. The gap in basic mental health care nationally, while not recorded, is significant.

This study aims to assess whether the Healthy Activity Program (HAP), a psychological intervention developed in India,31,32 can be feasibly delivered to PLHIV and people with TB with depression within the existing primary health care system in Lubombo. It seeks to explore acceptability among health care workers and patients. This study contributes to filling the gap in knowledge of mental health intervention delivery in resource-limited settings.

METHODS

This study used a modified version of HAP, a brief psychological treatment for depression that was developed in India by Sangath, that showed a positive effect when evaluated through a randomized controlled trial.31,32 The intervention involves training nonspecialist primary health care staff in the identification and causes of depression and, for those identified as having depression, using structured counseling based on behavioral activation theory with or without a referral to a doctor for further care.

Counseling consisted of 30–60 minutes sessions between individual participants and nurse counselors in the clinic with activity “homework” for participants between sessions. Key modifications from the original study were to (1) reduce the counselor’s manual size, (2) omit the patient manual (replacing vital content with handouts), (3) modify Indian-specific content, and (4) change counseling intervals from weekly to fortnightly. Modifications were made in recognition of the capacity of nurse counselors and patients, including limited literacy in the latter group, and were reviewed by individuals involved in the original study. Table 1 provides additional details about the intervention, including participants, setting, and process.33,34

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TABLE 1.

HAP Intervention for Depression Management Description

Evaluation

The evaluation of this study focused on investigating the feasibility and acceptability of this intervention. Feasibility was defined as the likelihood that an intervention can be recommended for further testing or scale-up and incorporates issues of demand, ease of implementation, and potential for expansion. In this context, feasibility was determined by the Ministry of Health. The study was able to make recommendations on feasibility based on the data on activity levels and interview data from nurse counselors and patients. These recommendations were presented to the Ministry of Health as a policy brief.35 Acceptability was defined as the “extent to which people delivering or receiving a health care intervention consider it to be appropriate, based on anticipated or experienced cognitive and emotional responses to the intervention.”36 This was explored from both patients’ and nurse counselors’ perspectives in the interview.

Basic quantitative service data on attendance, demographics, and Patient Health Questionnaire-9 (PHQ-9) scores were recorded and analyzed using descriptive statistics (percentage, mean, and median) in Microsoft Excel. The chi-square test was used to compare differences between categorical variables (R; version 4.2.1). Data were collected using data collection tools developed for this study to align with HIV care notes. The research assistant periodically collected the data in person from the facility-held notes.

Qualitative results were obtained via interviews with 16 patients and 6 nurse counselors purposively sampled to ensure diversity of characteristics, including gender, treatment site, and, for patients, PHQ-9 score. Patients were approached initially by their counselor, using a convenience sample, with no inclusion/exclusion criteria other than being eligible for the intervention. Nurse counselors, again using a convenience sample, were approached by the research assistant during routine study discussions, with the only inclusion/exclusion criteria that they were delivering counseling in this intervention. Interviews were undertaken at health care facilities. Patient travel costs were reimbursed (maximum of 200 Swazi emalangeni). Interviews were conducted in English by the research assistant with a siSwati translator.

The research team developed semistructured interview topic guides with a priori themes/codes and suggested probing questions. Counselor and patient topic guides were similar, both covering interviewees’ understandings of depression and experience of the study, including training (counselors only), recruitment/screening, and counseling. Patients were asked about their medical history, experiences of living with HIV and/or TB, and, if relevant, experience with antidepressants. Interview topic guides were piloted with minor language changes. Interviews occurred from May to August 2018. Interviews were audio-recorded, transcribed, and coded by 3 researchers according to the coding framework developed from interview themes. Given the similarity of counselor and patient topic guides, main codes were the same for both groups, although allowances were made for subcodes differing by group. All coded texts were checked independently by the in-country lead researcher. A framework analysis approach37 was used and a matrix developed with all coded texts under each theme per participant. The data under each theme were synthesized by 2 researchers, again independently checked by the lead researcher. All processes were discussed by this team to increase process validity and reliability.

Ethical Approval

All participants gave their informed, signed consent. Identifiable information was kept in a locked cabinet. Each participant was allocated a unique number that was linked to their name on the consent form, allowing study withdrawal. Digital information was held on password-protected laptops. The study was approved by the University of Leeds ethics board (MREC16-153) and the Eswatini National Health Research Review Board (17/01/2018, no assigned number).

RESULTS

Quantitative

Data were collected for 9 months of follow-up: March–October 2018. In March–April, 324 patients receiving either antiretrovirals or TB medication were screened for depression using the PHQ-9 at 8 sites across Lubombo. One site withdrew early due to staffing issues. At all sites, screening of all eligible patients was encouraged, and advice was given on managing practical and logistical barriers. However, in practice, screening was done ad hoc, depending on staff capacity, availability, and engagement. All data are rounded to 2 significant figures.

Among those with a documented disease status (accounting for the different denominators), 304 of 310 (98%) patients were HIV positive and 17 of 308 (6%) had TB (of whom 9 had drug-resistant disease). Of the total 324 patients, 62 patients screened positive (PHQ-9 score of 10 or higher), indicating a depression prevalence of 19% (95% confidence interval [CI]=15.1%, 24%). Patient variables are shown in Table 2.

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TABLE 2.

Demographics of All Patients Screened and Those Who Screened Positive for Depressiona

In this sample, the prevalence of depression was higher in men (23%) than in women (13%). The prevalence of depression was higher in those who were not currently employed (29%) compared to those employed (11%; P<.001). Nearly all patients screened for depression were HIV positive (93% of those screening positive, where their diagnosis was documented). The numbers for TB are too small to make any assertions, but 8 of 9 people screened with drug-resistant TB had moderate to severe depression. Of the 17 patients with TB, 12 were HIV positive, in line with national findings.29

All 62 patients who screened positive for depression were enrolled in HAP and accepted counseling. Two patients were thereafter withdrawn (their site withdrew). Thus, 60 patients were offered counseling. The median screening PHQ-9 score was 13 (interquartile range [IQR] 11–17). Figure 1 shows the distribution of PHQ-9 scores, with 81% having no features of depression, 13% having moderate depression, 5% having moderate to severe depression, and 2% having severe depression. Twenty-seven patients (44%) answered positively to question 9 (Q9) on suicidal ideation. Per the guideline of PHQ-9 score of 15 or higher or question 9 positive, 34 patients (55%) should have been referred, but only 13 were recorded as having been referred (11 to a doctor, with 5 prescribed antidepressants).

FIGURE 1
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FIGURE 1

Distribution of Patient Health Questionnaire-9 Scores on Screening Among Participants in the Health Activity Program, Eswatini

Of the 60 patients, 52 attended at least 1 counseling session. Figure 2 shows the variation in the total number of HAP sessions attended by each client, with the median number of sessions being 3 (IQR 1–5). The median interval between sessions was 29 days (IQR 24.5–45) (excluding between screening-counseling session 1 (S1) as this was 0 in 87% of patients). Mean session length was 27 minutes. Early in the evaluation process, the session interval frequency was modified to be monthly (from fortnightly) to coincide with HIV and TB medication collection and because shorter intervals proved to be unrealistic due to patient transport, time, and finances.

FIGURE 2
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FIGURE 2

Distribution of the Total Number of Healthy Activity Program Counseling Sessions Attended, per Participant, Eswatini

Qualitative

Table 3 shows nurse counselor characteristics, and Table 4 shows patient characteristics.

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TABLE 3.

Characteristics of Nurse Counselors Interviewed

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TABLE 4.

Characteristics of Patients Interviewed

Nine codes were identified a priori, each comprising 2–7 subcodes. An “other” code allowed for emergent themes. All codes are summarized:

  1. Intervention context

    • Understanding depression

    • HIV and/or TB and depression

    • Existing support and treatment

    • Barriers/facilitators to scale-up

  2. Intervention experiences

    • Screening and diagnosis

    • Referrals and antidepressant use

    • Counseling

Interview findings are discussed below using this framework. Counselors and patients expressed similar views, albeit often using different terms, reflecting their joint sociocultural experiences but different levels of medical education and different experiences of the intervention. Where views diverged, this is made clear in the text below.

Intervention Context

Depression, while often not named (with no direct translation into SiSwati), was recognized by counselors and patients—both in patients/themselves and in their communities. Multiple factors in this setting, including especially HIV, were recognized to have significant impacts on well-being. Despite this, both groups identified few or no prior strategies or management for depression in their settings, reinforcing concerns about a treatment gap. Counselors identified contextual barriers to scaling up this intervention, including workload, time, travel, and availability of complementary services.

Both counselors and patients identified few or no prior strategies or management for depression in their settings, reinforcing concerns about a treatment gap.

All interviewees understood depression as affecting mood and function. Counselors emphasized biological/circumstantial causes. Patients discussed their feelings, such as hopelessness, “fail to think straight,” and “heavy load on my chest.”

Suicide was mentioned by all but 1 counselor. Patients did not use this term, yet discussed death associated with depression.

Before [counseling] my life span was shortened. —Patient

If it wasn’t for the study maybe I would have been dead by now” —Patient

All interviewees discussed the psychological impact of having HIV and/or TB.

It really destroys the individual, mentally, emotionally, social [sic] and otherwise. —Nurse counselor

Patients discussed ostracism.

No one would touch anything from me, no one would eat with me, it was a very bad life. —Patient

Social isolation, stigma, and family issues were common, including suggestions of abuse (the latter discussed only by female participants)

He no longer treats me like he used to in the past, probably it’s because he knows I am positive…he is abusive. —Patient

A recurrent fear was that people would know or find out through medication, side effects, or visible symptoms.

Everyone now knows that [the patient] ha[s] HIV and this makes them depressed. —Nurse counselor

This was discussed concerning nonadherence alongside depression itself.

Sometimes you feel like even not even taking your medication. —Patient

Regarding existing support and treatment, all counselors expressed pre-pilot challenges in managing depression.

It was so frustrating because you would see that this person has got a problem but you did not have skills…to help them. —Nurse counselor

They reported lack of time, training, protocols, and systems.

Patients expressed concerns about confidentiality and cultural and social norms around discussing mood.

In my culture it is not allowed to disclose the problems you have in your household with your husband. —Patient

I never like to tell people my problems because others tend to judge you…if you tell them your problems they start telling others. —Patient

Overall, both groups felt this service should be scaled up, but logistics prevented this. Barriers to scale-up included staff capacity, privacy, space, patients not attending sessions, and patient finances affecting health care access (travel/time off work). Time was a recurrent issue for counselors and patients.

It takes a lot of time for them to go through that process … patients will be…impatient because they will be wanting to go because they've taken so much time in the clinic going through the process of refilling their medication and now you want to go for a forty-minute session of counseling… —Nurse counselor

I’m a seasonal worker so I cannot come every month it might disturb my job. —Patient

Both counselors and patients felt the program should be scaled up, but logistical barriers prevented this.

To facilitate scale-up, counselors recommended further task-shifting/increasing workforce capacity, as well as sensitizing and engaging stakeholders and the public.

Counselors also identified that some stressors identified by participants (e.g., intractable financial problems) were less suited to a problem-solving approach.

[Patients] needed financial assistance…we try…but we could not help them —Nurse counselor

Other problems (e.g., previous traumatic experiences) were felt to be too complex to be addressed using the HAP approach alone and were likely to require additional specialist psychological input.

Our clients here [have] problems which are a bit…difficult and HAP doesn’t really get into them so deep. —Nurse counselor

Intervention Experiences

Counselors and patients indicate that they found screening, diagnosis, and counseling broadly acceptable. However, they expressed some concerns about the need to repeat the PHQ-9 assessment at each session. Counselors appreciated the clear guidance on when to refer patients (although referral pathways remained an issue as outlined in the quantitative data and discussed later).

Generally, both counselors and patients found the PHQ-9 easy to use and helpful in identifying depression. Patients reported diagnosis as “shock/unexpected” sometimes followed by anticipation.

It made me have something to live for, it made it clear that there was help on the way. —Patient

They gave me hope. —Patient

Some patients struggled with the screening.

I was hiding the feeling…I didn’t like them asking me what is wrong, I wanted it to be a secret. —Patient

You feel like you are being exposed. —Patient

Counselors discussed logistical issues, including lacking capacity to systematically screen patients due to workload, lack of space and privacy, and issues with language.

Most clients felt it’s a bit difficult for them even if they were siSwati speakers. —Nurse counselor

Regarding referrals, counselors responded favorably to the referral guidelines, yet they reported challenges in monitoring whether patients attended, with no mechanism to confirm referral.

In both patients and counselors, there was increased awareness of depression. Counselors found counseling fulfilling. All patients and 3 counselors reported mood improvements in patients. Both patients and counselors deemed the use of “behavioral activation” helpful, with patients suggesting activities, but some required more sociocultural sensitivity.

What surprised me is when the counselor told me to go and exercise because how was I going to exercise as I normally work. —Patient

[Patients] would come back without doing the given tasks stating that they thought they were not important. —Nurse counselor

All patients interviewed reported mood improvements after attending counseling.

Counselors suggested some positive impacts on medication adherence.

Regarding using the PHQ-9 at each session to monitor response, counselors expressed concerns.

Patients become used to the tool and they lie. —Nurse counselor

In general, patients found the tool useful, but negative responses existed, including concerns about exhaustion and repetition.

DISCUSSION

This study contributes important evidence to the World Health Organization’s call to improve mental health for all38 in a particularly at-risk group in an understudied setting. It furthers unde-standing of the integration of mental health into primary care, in addition to advocating for a low-resource, replicable method to do this.

This study found depression to be common among PLHIV and people with TB in this context. Our analysis indicates that, while there are some potential benefits to HAP in this setting, there are caveats in terms of feasibility and acceptability for patients and the health system.

Feasibility and Acceptability

Qualitative results suggest acceptability of this program. However, it should be noted the lack of qualitative evidence from patients not attending counseling weakens this assertion. There were positive accounts of HAP on patients’ lives, mood, and well-being. However, the quantitative results indicate that patients did not attend a suggested course (5–8 sessions) in 9 months of follow-up. While a degree of attrition may be expected in psychological therapies, this is potentially excessive. This observation puts into question both the feasibility and acceptability of the 9-month course duration in this setting. In future practice or research, shorter courses could be trialed, and patients could be explicitly asked beforehand of the potential barriers affecting attendance so that potential mitigating factors could be put in place. While this was unfortunately not possible in this pilot, future research should attempt to follow up with patients no longer attending counseling.

There were concerns about the validity and reliability of the PHQ-9 used as a screening tool in this way, where it is not validated. Median PHQ-9 scores dropped sharply after 1 session, suggestive of a factor other than treatment effectiveness. While this study does not aim and is not powered to assess effectiveness, these findings raise questions about the use of this tool, despite its validity in similar settings.39–41 Interviews with counselors introduced speculation as to whether initial scores were artificially inflated due to misunderstandings (there is no term for depression in siSwati, and questions proved complex to translate) or transient interference of HIV and/or TB symptoms or medication side effects, thus causing the PHQ-9 to improve rapidly at later sessions. This is conjecture; however, these concerns align with previous evidence, where a risk of false positives in screening tools for depression among PLHIV was recognized in a review across Africa.42 This complicates any assessment of feasibility, as it is unclear whether our patient selection was correct. Alternatively, there were concerns that patients purposefully lowered their scores to please the counselor or expedite the end of the sessions, with implications on acceptability. Such concerns could be addressed with a randomized controlled trial, which we recommend for this context.

Concerns expressed by health care professionals about the sustainability of this intervention centered around their capacity, space, and workload, reinforced by 1 site withdrawing early in the study. Nurses have little spare capacity and many competing priorities, inhibiting their ability to deliver 30-minute sessions while providing care to other patients. A feasibility study conducted in South Africa with a similar intervention for people living with HIV and/or diabetes found similar rates of feasibility and acceptability for “designated” (alongside usual duties) and “dedicated” (sole responsibility) health care workers.43 A further small study (n=14) in South Africa suggested acceptability and a positive impact on adherence to this intervention but again concerns around feasibility (in this case, around provider fidelity to the intervention).44 A study in Zimbabwe implemented more supervision, mentoring, and allocated time for their nurse counselors for this intervention and indicated better treatment adherence.45 These additional support measures may improve feasibility, acceptability, and patient adherence. None of these relatively small studies are conclusive. However, they indicate that integration is feasible into routine care and that a careful balance of workforce support and health care support is required. These studies also involved other/lay health cadres, which was a suggestion raised by our counselors and one we advocate to pursue in further research.

Issues around referrals could be interpreted in 2 ways: (1) patients did not want or could not attend; or (2) referral pathways and quality accessible secondary mental health care were lacking. These indicate a lack of acceptability (by patients) and/or feasibility (insufficient mental health infrastructure).

Prevalence

Almost one-fifth of those with HIV and/or TB who were screened were diagnosed with depression, with a high proportion of suicidal ideation. These small numbers should be interpreted cautiously yet earnestly, given alignment with existing evidence46 and reinforcement by qualitative results. Having HIV and/or TB and poverty, traumatic events, familial and community pressures intersect, placing this population at a high risk of mental disorders. Our findings support the view that stigma related to HIV and/or TB increases the risk of mental disorders and adversely affects HIV47 and TB48 outcomes, findings replicated in Eswatini.49

Recommendations for Policy and Practice

This pilot study shows substantial unmet needs and potential benefits of this approach, as well as feasibility concerns. Training nonspecialist health care staff in common mental disorders is recognized globally as essential to managing the treatment gap,38 and integration with HIV and TB care is critical.12,50 But there are meaningful human resource constraints. Implementation needs to be realistic, sensitive, and pragmatic. In an integrated service and in the absence of additional staff, there is an opportunity cost to other services that may be inappropriate. Wider education and community engagement are necessary to reduce stigma and raise the profile of mental disorders in a manner that supports acceptance of talking therapies. These findings broadly align with similar research.51

Limitations

This was a small pilot in line with the values and aims of implementation research; it was pragmatic, operational, and collaborative.52 There are benefits to this methodology, but in addition to its relatively small scale, limitations warrant discussion. In all stages of this study, this approach impeded ideal implementation, including participating clinic and nurse selection, lack of systematic screening, and an inability to follow up on missing information that affected data completeness. The low number of patients referred to a doctor was concerning and a major limitation of this study, especially given their higher risk of harm. This was flagged during the pilot, yet there are no longitudinal data to assess their follow-up or management. We were not able to follow up these patients, given a lack of contact details and reporting delays. Upon questioning, many counselors reported that patients refused referral due to cost of travel or unspecified reasons.

Interviews were only feasible with patients who attended counseling; hence, the experiences of those not attending were not captured and limited our conclusion on acceptability. Informal discussions with health care staff suggest nonattendance was due to a combination of factors, including patients’ lacking time, lack of cultural norms around counseling, and organizational issues meaning counselors were not aware patients were present, although this is conjecture. For future longer-term evaluation of this intervention, this needs to be a key focus of investigation and follow-up.

Fidelity to intervention delivery over time was insufficiently assessed in this pragmatic pilot, and this weakens our understanding of both acceptability and feasibility. The mean session length (27 minutes) indicates some alignment with the suggested timings, and interviews indicate some fidelity. However, it is difficult to adequately assess how HAP counseling differed from the more unstructured support routinely provided by nurses in these settings, especially over time. This warrants further monitoring in future studies.

Finally, the clinical psychologist was not effectively or appropriately used, with reasons not fully understood. Supervision and mentoring are important elements of task-shifting and may have improved safety, quality, fidelity, and feasibility.

CONCLUSION

This intervention is promising and generates useful recommendations on feasibility. Real-life application is tempered by health system resources and capacity, workforce availability, and training constraints. Patients’ ability to complete a course is limited by travel costs, time, and social barriers—all issues not unique to Eswatini. This small study is an incremental step to understanding the challenges, complexities, and successes of implementing a contextualized mental health package in a setting with little alternative access to care for individuals with common mental health problems but who have great need.

Acknowledgments

We thank all our colleagues at Good Shepherd Hospital, Lubombo Regional Health Office, Lubombo Health Research Unit, and the Kingdom of Eswatini Ministry of Health.

Funding

This work was supported by the Department for International Development, United Kingdom (under grant COMDIS-HSD RGNUID 48065).

Author contributions

NP, NR, PS, and VM led the implementation and research in country, supported by AN, DB, and AB. Academic and technical advice and guidance were provided by JW (as principal investigator), IW, and RK. NP led the article writing, with all authors reviewing and contributing to the draft.

Competing interests

None declared.

Notes

Peer Reviewed

First published online: March 29, 2023.

Cite this article as: Putnis N, Riches N, Nyamayaro A, et al. Evaluation of a depression intervention in people with HIV and/or TB in Eswatini primary care facilities: implications for Southern Africa. Glob Health Sci Pract. 2023;11(2):e2200016. https://doi.org/10.9745/GHSP-D-22-00016

  • Received: January 19, 2022.
  • Accepted: February 14, 2023.
  • Published: April 28, 2023.
  • © Putnis et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly cited. To view a copy of the license, visit https://creativecommons.org/licenses/by/4.0/. When linking to this article, please use the following permanent link: https://doi.org/10.9745/GHSP-D-22-00016

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Global Health: Science and Practice: 11 (2)
Global Health: Science and Practice
Vol. 11, No. 2
April 28, 2023
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Evaluation of a Depression Intervention in People With HIV and/or TB in Eswatini Primary Care Facilities: Implications for Southern Africa
Nina Putnis, Nick Riches, Archibald Nyamayaro, Darah Boucher, Rebecca King, Ian F. Walker, Alett Burger, Paul Southworth, Violet Mwanjali, John Walley
Global Health: Science and Practice Apr 2023, 11 (2) e2200016; DOI: 10.9745/GHSP-D-22-00016

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Evaluation of a Depression Intervention in People With HIV and/or TB in Eswatini Primary Care Facilities: Implications for Southern Africa
Nina Putnis, Nick Riches, Archibald Nyamayaro, Darah Boucher, Rebecca King, Ian F. Walker, Alett Burger, Paul Southworth, Violet Mwanjali, John Walley
Global Health: Science and Practice Apr 2023, 11 (2) e2200016; DOI: 10.9745/GHSP-D-22-00016
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