User profiles for Wenjian Yang
 | Wenjian YangSt Jude Children's Research Hospital Verified email at stjude.org Cited by 14318 |
[HTML][HTML] Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia
Background Despite best current therapy, up to 20% of pediatric patients with acute lymphoblastic
leukemia (ALL) have a relapse. Recent genomewide analyses have identified a high …
leukemia (ALL) have a relapse. Recent genomewide analyses have identified a high …
[HTML][HTML] Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment
Background Childhood acute lymphoblastic leukemia (ALL) is curable with chemotherapy
in approximately 80 percent of patients. However, the cause of treatment failure in the …
in approximately 80 percent of patients. However, the cause of treatment failure in the …
Germline genomic variants associated with childhood acute lymphoblastic leukemia
Using the Affymetrix 500K Mapping array and publicly available genotypes, we identified 18
SNPs whose allele frequency differed significantly(P < 1 × 10 −5 ) between pediatric acute …
SNPs whose allele frequency differed significantly(P < 1 × 10 −5 ) between pediatric acute …
NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity
Widely used as anticancer and immunosuppressive agents, thiopurines have narrow therapeutic
indices owing to frequent toxicities, partly explained by TPMT genetic polymorphisms. …
indices owing to frequent toxicities, partly explained by TPMT genetic polymorphisms. …
[HTML][HTML] Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia
Purpose Mercaptopurine (MP) is the mainstay of curative therapy for acute lymphoblastic
leukemia (ALL). We performed a genome-wide association study (GWAS) to identify …
leukemia (ALL). We performed a genome-wide association study (GWAS) to identify …
[HTML][HTML] Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects
LR Treviño, N Shimasaki, W Yang… - Journal of Clinical …, 2009 - ncbi.nlm.nih.gov
… Treviño, Noriko Shimasaki, Wenjian Yang, John C. Panetta, Cheng Cheng, Deqing Pei,
Diana Chan, Alex Sparreboom, Kathleen M. Giacomini, Ching-Hon Pui, William E …
Diana Chan, Alex Sparreboom, Kathleen M. Giacomini, Ching-Hon Pui, William E …
Multiplex assessment of protein variant abundance by massively parallel sequencing
Determining the pathogenicity of genetic variants is a critical challenge, and functional
assessment is often the only option. Experimentally characterizing millions of possible missense …
assessment is often the only option. Experimentally characterizing millions of possible missense …
Applications of metal-organic framework (MOF)-based sensors for food safety: Enhancing mechanisms and recent advances
W Cheng, X Tang, Y Zhang, D Wu, W Yang - Trends in Food Science & …, 2021 - Elsevier
Background Increasing requirements for rapid and reliable food safety control demands new
sensing techniques with excellent performance. Metal-organic framework (MOF), as a class …
sensing techniques with excellent performance. Metal-organic framework (MOF), as a class …
Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse
Recent genomic profiling of childhood acute lymphoblastic leukemia (ALL) identified a high-risk
subtype with an expression signature resembling that of Philadelphia chromosome–…
subtype with an expression signature resembling that of Philadelphia chromosome–…
PG4KDS: a model for the clinical implementation of pre‐emptive pharmacogenetics
…, DK Baker, NM Kornegay, W Yang… - American Journal of …, 2014 - Wiley Online Library
Pharmacogenetics is frequently cited as an area for initial focus of the clinical implementation
of genomics. Through the PG4KDS protocol, St. Jude Children's Research Hospital pre‐…
of genomics. Through the PG4KDS protocol, St. Jude Children's Research Hospital pre‐…