Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

…, R Greenwood, VA Mitchell… - British journal of …, 2006 - Wiley Online Library
While cannabinoid receptor agonists have analgesic activity in chronic pain states, they
produce a spectrum of central CB 1 receptor‐mediated motor and psychotropic side effects. The …

[HTML][HTML] Food patterns according to sociodemographics, physical activity, sleeping and obesity in Portuguese children

…, H Valente, R Barros, V Teixeira, V Mitchell… - International journal of …, 2010 - mdpi.com
Our study aimed to describe the association between food patterns and gender, parental
education, physical activity, sleeping and obesity in 1976 children aged 5−10 years old. Dietary …

Opioid and cannabinoid synergy in a mouse neuropathic pain model

…, SL Casey, PW Seow, VA Mitchell… - British Journal of …, 2016 - Wiley Online Library
Background and Purpose Clinical studies have reported that pan‐cannabinoid receptor
agonists may have efficacy in neuropathic pain states and that this might be enhanced by co‐…

Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model

NS Adamson Barnes, VA Mitchell… - British Journal of …, 2016 - Wiley Online Library
Background and Purpose While cannabinoids have been proposed as a potential treatment
for neuropathic pain, they have limitations. Cannabinoid receptor agonists have good …

Glutamate spillover modulates GABAergic synaptic transmission in the rat midbrain periaqueductal grey via metabotropic glutamate receptors and endocannabinoid …

GM Drew, VA Mitchell, CW Vaughan - Journal of Neuroscience, 2008 - Soc Neuroscience
Glutamate spillover regulates GABAergic synaptic transmission at several CNS synapses
via presynaptic ionotropic and metabotropic glutamate receptors (mGluRs). We have …

Role of 5‐HT1 receptor subtypes in the modulation of pain and synaptic transmission in rat spinal superficial dorsal horn

HJ Jeong, VA Mitchell… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE 5‐HT receptor agonists have variable nociceptive effects
within the spinal cord. While there is some evidence for 5‐HT 1A spinally‐mediated analgesia…

Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model

WB Anderson, MJ Gould, RD Torres, VA Mitchell… - …, 2014 - Elsevier
The analgesic efficacy of cannabinoids in chronic pain models is limited by side-effects. It
has been proposed that this might be overcome by using agents which indirectly activate the …

Oral efficacy of Δ (9)-tetrahydrocannabinol and cannabidiol in a mouse neuropathic pain model

VA Mitchell, J Harley, SL Casey, AC Vaughan… - …, 2021 - Elsevier
The psychoactive and non-psychoactive constituents of cannabis, Δ9-tetrahydrocannabinol (THC)
and cannabidiol (CBD), have synergistic analgesic efficacy in animal models of …

Actions of N-arachidonyl-glycine in a rat neuropathic pain model

LAQ Vuong, VA Mitchell, CW Vaughan - Neuropharmacology, 2008 - Elsevier
While cannabinoid receptor agonists reduce the abnormal pain sensations associated with
animal models of neuropathic pain states they also produce CB 1 receptor mediated side …

[HTML][HTML] Intrathecal actions of the cannabis constituents Δ (9)-tetrahydrocannabinol and cannabidiol in a mouse neuropathic pain model

SL Casey, VA Mitchell, EE Sokolaj, BL Winters… - International Journal of …, 2022 - mdpi.com
(1) Background: The psychoactive and non-psychoactive constituents of cannabis, Δ9-tetrahydrocannabinol
(THC) and cannabidiol (CBD), synergistically reduce allodynia in various …