Superoxide dismutases are an ubiquitous family of enzymes that function to efficiently
catalyze the dismutation of superoxide anions. Three unique and highly compartmentalized …

Excessive production and/or inadequate removal of reactive oxygen species, especially
superoxide anion (O 2 •− ), have been implicated in the pathogenesis of many cardiovascular …

Radiation therapy (RT) for thoracic-region tumors often causes lung injury. The incidence of
lung toxicity depends on the method of assessment (eg, radiographs, patient’s symptoms, or …

Background Despite current therapies, diffuse cutaneous systemic sclerosis (scleroderma)
often has a devastating outcome. We compared myeloablative CD34+ selected autologous …

Rationale: Acute lung dysfunction of noninfectious etiology, known as idiopathic pneumonia
syndrome (IPS), is a severe complication following hematopoietic stem cell transplantation (…

Delayed neurological damage after CO hypoxia was studied in rats to determine whether
programmed cell death (PCD), in addition to necrosis, is involved in neuronal death. In rats …

Chronic exposure to low-O 2 tension induces pulmonary arterial hypertension (PAH), which
is characterized by vascular remodeling and enhanced vasoreactivity. Recent evidence …

Extracellular superoxide dismutase (EC-SOD, or SOD3) is the major extracellular antioxidant
enzyme in the lung. To study the biologic role of EC-SOD in hyperoxic-induced pulmonary …

Background Many persons with a history of smoking tobacco have clinically significant
respiratory symptoms despite an absence of airflow obstruction as assessed by spirometry. They …

We have isolated and characterized over 10,000 bp of the human EC SOD gene (SOD3 or
EC 1.15.1.1) and its 5′- and 3′-flanking regions. Human genomic Southern blot analysis …