In June 2000, the United States National Institutes of Health (NIH) organized a review of the
scientific evidence on the effectiveness of condoms in preventing sexually transmitted …

Medical providers are trained to investigate, diagnose, and treat cancer. Their primary goal
is to maximize the chances of curing the patient, with less training provided on palliative care …

Conspectus An ortho-quinone methide (o-QM) is a highly reactive chemical motif harnessed
by nature for a variety of purposes. Given its extraordinary reactivity and biological …

DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned
the discovery of all classes of cis-regulatory elements including enhancers, promoters, …

Genetic variation among individual humans occurs on many different scales, ranging from
gross alterations in the human karyotype to single nucleotide changes. Here we explore …

Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016
provides an up-to-date analysis of the burden of diarrhoea in 195 countries. This study …

Background The prevalence and spectrum of predisposing mutations among children and
adolescents with cancer are largely unknown. Knowledge of such mutations may improve the …

Background Rindopepimut (also known as CDX-110), a vaccine targeting the EGFR deletion
mutation EGFRvIII, consists of an EGFRvIII-specific peptide conjugated to keyhole limpet …

Regulatory factor binding to genomic DNA protects the underlying sequence from cleavage
by DNase I, leaving nucleotide-resolution footprints. Using genomic DNase I footprinting …

The topic of feedback to students is an under‐researched area, and there has been little
empirical research published which focuses on student perceptions. This study explores student …