The importance of circulating free DNA (cfDNA) in cancer clinical research was recognized
in 1994 when a mutated RAS gene fragment was detected in a patient’s blood sample. Up to …

Matriptase and its cognate, Kunitz-type serine protease inhibitor, HAI-1, comprise a newly
characterized extracellular matrix-degrading protease system that may function as an …

Introduction: Medical diagnostics is a critical element of effective medical treatment. However,
many modern and emerging diagnostic technologies are not affordable or compatible with …

Many cancers evolve from benign precancerous lesions and have a natural history of
progression that provides a window of opportunity for intervention. The biological mechanisms …

… Divi is with the National Cancer Institute, Rockville, MD 20850 USA (e-mail: divir@dc37a.nci.nih.gov)
M. Ossandon is with the National Cancer Institute, Rockville, MD 20850 USA (e-…

OBJECTIVE: Neovascularization is a response of tissue to ischemic damage. Placental
ischemia is thought to underlie a significant portion of preterm deliveries. Our objective was to …

A Lab-on-a-chip (LOC) was designed, fabricated and tested for the in vitrodetection of
botulinum neurotoxin serotype A (BoNT-A) activity using an assay that measures cleavage of a …

In this paper, we describe a simple charge-coupled device (CCD) based lensless fluorometer
with sensitivity in the range of current ELISA plate readers. In our lensfree fluorometer, a …

… The m-health revolution has had a profound effect on the global community, as many of
the lowest-resource populations still have widespread access to mobile devices. While m-health …

OBJECTIVE: To determine the stability of cytokines in frozen stored amniotic fluid samples,
we measured angiogenin, a potent inducer of neovascularization and interleukin-6, an …