User profiles for Douglas Taylor

Douglas Taylor

University of Virginia
Verified email at virginia.edu
Cited by 7766

[HTML][HTML] Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

…, P Siljander, A Stensballe, W Stoorvogel, D Taylor… - PLoS …, 2012 - journals.plos.org
Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into
their microenvironment. Recent studies have elucidated the role of EVs in intercellular …

Retracted: microRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

DD Taylor, C Gercel-Taylor - 2008 - Elsevier
OBJECTIVES: Most ovarian cancer patients are diagnosed at an advanced stage (67%) and
prospects for significant improvement in survival reside in early diagnosis. While expression …

Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women

…, N Arulappan, M Mlotshwa, L Morris, D Taylor… - science, 2010 - science.org
The Centre for the AIDS Program of Research in South Africa (CAPRISA) 004 trial assessed
the effectiveness and safety of a 1% vaginal gel formulation of tenofovir, a nucleotide …

Exosomal microRNA: a diagnostic marker for lung cancer

G Rabinowits, C Gerçel-Taylor, JM Day, DD Taylor… - Clinical lung cancer, 2009 - Elsevier
Purpose To date, there is no screening test for lung cancer shown to affect overall mortality.
MicroRNAs (miRNAs) are a class of small noncoding RNA genes found to be abnormally …

[HTML][HTML] Preexposure prophylaxis for HIV infection among African women

…, J Deese, T Crucitti, TD Mastro, D Taylor - … England Journal of …, 2012 - Mass Medical Soc
Background Preexposure prophylaxis with antiretroviral drugs has been effective in the
prevention of human immunodeficiency virus (HIV) infection in some trials but not in others. …

Defective angiogenesis in mice lacking endoglin

…, BS Brooke, LD Urness, EC Davis, DG Taylor… - Science, 1999 - science.org
Endoglin is a transforming growth factor–β (TGF-β) binding protein expressed on the surface
of endothelial cells. Loss-of-function mutations in the human endoglin gene ENGcause …

[HTML][HTML] Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells

JW Chan, DS Taylor, T Zwerdling, SM Lane, K Ihara… - Biophysical journal, 2006 - cell.com
Current methods for identifying neoplastic cells and discerning them from their normal
counterparts are often nonspecific, slow, biologically perturbing, or a combination thereof. Here, …

Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes

DD Taylor, S Shah - Methods, 2015 - Elsevier
Viable tumor cells actively release vesicles into the peripheral circulation and other biologic
fluids, which exhibit proteins and RNAs characteristic of that cell. Our group demonstrated …

Fas ligand–positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes

JW Kim, E Wieckowski, DD Taylor, TE Reichert… - Clinical Cancer …, 2005 - AACR
Objective: In patients with oral squamous cell carcinoma, a high proportion of T cells in the
tumor undergo apoptosis, which correlates with Fas ligand (FasL) expression on tumor cells. …

[HTML][HTML] Rapid evolution of enormous, multichromosomal genomes in flowering plant mitochondria with exceptionally high mutation rates

…, M Wu, DE McCauley, JD Palmer, DR Taylor - PLoS …, 2012 - journals.plos.org
Genome size and complexity vary tremendously among eukaryotic species and their
organelles. Comparisons across deeply divergent eukaryotic lineages have suggested that …